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L-glutamine decreases the severity of mucositis induced by chemoradiotherapy in patients with locally advanced head and neck cancer: A double-blind, randomized, placebo-controlled trial
The incidence of severe mucositis in the oral cavity, pharynx and larynx is high among patients with head and neck cancer (HNC) receiving chemoradiotherapy (CRT), resulting in significant pain and impairment of quality of life. The present study investigated whether L-glutamine (glutamine) decreases...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254677/ https://www.ncbi.nlm.nih.gov/pubmed/25351453 http://dx.doi.org/10.3892/or.2014.3564 |
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author | TSUJIMOTO, TAKAE YAMAMOTO, YOSHIFUMI WASA, MASAFUMI TAKENAKA, YUKINORI NAKAHARA, SUSUMU TAKAGI, TASTUYA TSUGANE, MAMIKO HAYASHI, NORIYUKI MAEDA, KAZUHISA INOHARA, HIDENORI UEJIMA, ETSUKO ITO, TOSHINORI |
author_facet | TSUJIMOTO, TAKAE YAMAMOTO, YOSHIFUMI WASA, MASAFUMI TAKENAKA, YUKINORI NAKAHARA, SUSUMU TAKAGI, TASTUYA TSUGANE, MAMIKO HAYASHI, NORIYUKI MAEDA, KAZUHISA INOHARA, HIDENORI UEJIMA, ETSUKO ITO, TOSHINORI |
author_sort | TSUJIMOTO, TAKAE |
collection | PubMed |
description | The incidence of severe mucositis in the oral cavity, pharynx and larynx is high among patients with head and neck cancer (HNC) receiving chemoradiotherapy (CRT), resulting in significant pain and impairment of quality of life. The present study investigated whether L-glutamine (glutamine) decreases the severity of mucositis in the oral cavity, pharynx and larynx induced by CRT. This double-blind, randomized, placebo-controlled trial included 40 untreated patients with squamous cell carcinoma of the nasopharynx, oropharynx, hypopharynx or larynx. Patients received 66 or 70 Gy of total radiation at the rate of 2 Gy/fraction daily and 5 fractions/week. Cisplatin (20 mg/m(2)) and docetaxel (10 mg/m(2)) were intravenously co-administered once a week for 6 weeks. Patients were randomized to orally receive either glutamine (group G) or placebo (group P) at a dose of 10 g 3 times a day throughout the CRT course. Mucositis was assessed using the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0. The primary end point was mucositis severity. Mucositis developed in all patients. A maximal mucositis grade of G4 was observed in 0 and 25% group G and P patients, respectively, while that of G2 was observed in 10 and 0% group G and P patients, respectively (p=0.023). Glutamine significantly decreased the maximal mucositis grade (group G, 2.9±0.3; group P, 3.3±0.4; p=0.005) and pain score at weeks 4, 5 and 6. Glutamine significantly decreased mucositis severity in the oral cavity, pharynx and larynx induced by CRT in patients with HNC. |
format | Online Article Text |
id | pubmed-4254677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-42546772014-12-05 L-glutamine decreases the severity of mucositis induced by chemoradiotherapy in patients with locally advanced head and neck cancer: A double-blind, randomized, placebo-controlled trial TSUJIMOTO, TAKAE YAMAMOTO, YOSHIFUMI WASA, MASAFUMI TAKENAKA, YUKINORI NAKAHARA, SUSUMU TAKAGI, TASTUYA TSUGANE, MAMIKO HAYASHI, NORIYUKI MAEDA, KAZUHISA INOHARA, HIDENORI UEJIMA, ETSUKO ITO, TOSHINORI Oncol Rep Articles The incidence of severe mucositis in the oral cavity, pharynx and larynx is high among patients with head and neck cancer (HNC) receiving chemoradiotherapy (CRT), resulting in significant pain and impairment of quality of life. The present study investigated whether L-glutamine (glutamine) decreases the severity of mucositis in the oral cavity, pharynx and larynx induced by CRT. This double-blind, randomized, placebo-controlled trial included 40 untreated patients with squamous cell carcinoma of the nasopharynx, oropharynx, hypopharynx or larynx. Patients received 66 or 70 Gy of total radiation at the rate of 2 Gy/fraction daily and 5 fractions/week. Cisplatin (20 mg/m(2)) and docetaxel (10 mg/m(2)) were intravenously co-administered once a week for 6 weeks. Patients were randomized to orally receive either glutamine (group G) or placebo (group P) at a dose of 10 g 3 times a day throughout the CRT course. Mucositis was assessed using the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0. The primary end point was mucositis severity. Mucositis developed in all patients. A maximal mucositis grade of G4 was observed in 0 and 25% group G and P patients, respectively, while that of G2 was observed in 10 and 0% group G and P patients, respectively (p=0.023). Glutamine significantly decreased the maximal mucositis grade (group G, 2.9±0.3; group P, 3.3±0.4; p=0.005) and pain score at weeks 4, 5 and 6. Glutamine significantly decreased mucositis severity in the oral cavity, pharynx and larynx induced by CRT in patients with HNC. D.A. Spandidos 2015-01 2014-10-23 /pmc/articles/PMC4254677/ /pubmed/25351453 http://dx.doi.org/10.3892/or.2014.3564 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles TSUJIMOTO, TAKAE YAMAMOTO, YOSHIFUMI WASA, MASAFUMI TAKENAKA, YUKINORI NAKAHARA, SUSUMU TAKAGI, TASTUYA TSUGANE, MAMIKO HAYASHI, NORIYUKI MAEDA, KAZUHISA INOHARA, HIDENORI UEJIMA, ETSUKO ITO, TOSHINORI L-glutamine decreases the severity of mucositis induced by chemoradiotherapy in patients with locally advanced head and neck cancer: A double-blind, randomized, placebo-controlled trial |
title | L-glutamine decreases the severity of mucositis induced by chemoradiotherapy in patients with locally advanced head and neck cancer: A double-blind, randomized, placebo-controlled trial |
title_full | L-glutamine decreases the severity of mucositis induced by chemoradiotherapy in patients with locally advanced head and neck cancer: A double-blind, randomized, placebo-controlled trial |
title_fullStr | L-glutamine decreases the severity of mucositis induced by chemoradiotherapy in patients with locally advanced head and neck cancer: A double-blind, randomized, placebo-controlled trial |
title_full_unstemmed | L-glutamine decreases the severity of mucositis induced by chemoradiotherapy in patients with locally advanced head and neck cancer: A double-blind, randomized, placebo-controlled trial |
title_short | L-glutamine decreases the severity of mucositis induced by chemoradiotherapy in patients with locally advanced head and neck cancer: A double-blind, randomized, placebo-controlled trial |
title_sort | l-glutamine decreases the severity of mucositis induced by chemoradiotherapy in patients with locally advanced head and neck cancer: a double-blind, randomized, placebo-controlled trial |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254677/ https://www.ncbi.nlm.nih.gov/pubmed/25351453 http://dx.doi.org/10.3892/or.2014.3564 |
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