Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy

The progression of many solid tumors is driven by de-regulation of multiple common pathways, particularly Rb, PI (3) K/Akt and p53. Prior studies identified TopBP1as a key mediator for the oncogenic gain-of-function activities of mutant p53 (mutp53) in cancer. In Akt-hyperactive cancer, TopBP1 forms...

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Detalles Bibliográficos
Autores principales: Chowdhury, Pinki, Lin, Gregory E., Liu, Kang, Song, Yongcheng, Lin, Fang-Tsyr, Lin, Weei-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254804/
https://www.ncbi.nlm.nih.gov/pubmed/25400145
http://dx.doi.org/10.1038/ncomms6476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254804/
https://www.ncbi.nlm.nih.gov/pubmed/25400145
http://dx.doi.org/10.1038/ncomms6476

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