MicroRNA Expression Profiling in PBMCs: A Potential Diagnostic Biomarker of Chronic Hepatitis C

The expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 in PBMCs were significantly higher in CHC patients compared with healthy controls and significantly different between CHC patients with HCV genotype 1 (GT-1) and non-genotype-1 (non-GT-1). Multivariate logistic regression anal...

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Autores principales: Chang, Chiu-Chun, Lin, Chun-Che, Hsieh, Wan-Ling, Lai, Hsin-Wu, Tsai, Chia-Hsun, Cheng, Ya-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255053/
https://www.ncbi.nlm.nih.gov/pubmed/25505813
http://dx.doi.org/10.1155/2014/367157
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author Chang, Chiu-Chun
Lin, Chun-Che
Hsieh, Wan-Ling
Lai, Hsin-Wu
Tsai, Chia-Hsun
Cheng, Ya-Wen
author_facet Chang, Chiu-Chun
Lin, Chun-Che
Hsieh, Wan-Ling
Lai, Hsin-Wu
Tsai, Chia-Hsun
Cheng, Ya-Wen
author_sort Chang, Chiu-Chun
collection PubMed
description The expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 in PBMCs were significantly higher in CHC patients compared with healthy controls and significantly different between CHC patients with HCV genotype 1 (GT-1) and non-genotype-1 (non-GT-1). Multivariate logistic regression analysis also showed that patients with high expression levels of the six target miRNAs had an approximately 7.202-fold risk of CHC compared with those with low expression levels of the target miRNAs. We concluded that the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC.
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spelling pubmed-42550532014-12-11 MicroRNA Expression Profiling in PBMCs: A Potential Diagnostic Biomarker of Chronic Hepatitis C Chang, Chiu-Chun Lin, Chun-Che Hsieh, Wan-Ling Lai, Hsin-Wu Tsai, Chia-Hsun Cheng, Ya-Wen Dis Markers Research Article The expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 in PBMCs were significantly higher in CHC patients compared with healthy controls and significantly different between CHC patients with HCV genotype 1 (GT-1) and non-genotype-1 (non-GT-1). Multivariate logistic regression analysis also showed that patients with high expression levels of the six target miRNAs had an approximately 7.202-fold risk of CHC compared with those with low expression levels of the target miRNAs. We concluded that the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC. Hindawi Publishing Corporation 2014 2014-11-18 /pmc/articles/PMC4255053/ /pubmed/25505813 http://dx.doi.org/10.1155/2014/367157 Text en Copyright © 2014 Chiu-Chun Chang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chang, Chiu-Chun
Lin, Chun-Che
Hsieh, Wan-Ling
Lai, Hsin-Wu
Tsai, Chia-Hsun
Cheng, Ya-Wen
MicroRNA Expression Profiling in PBMCs: A Potential Diagnostic Biomarker of Chronic Hepatitis C
title MicroRNA Expression Profiling in PBMCs: A Potential Diagnostic Biomarker of Chronic Hepatitis C
title_full MicroRNA Expression Profiling in PBMCs: A Potential Diagnostic Biomarker of Chronic Hepatitis C
title_fullStr MicroRNA Expression Profiling in PBMCs: A Potential Diagnostic Biomarker of Chronic Hepatitis C
title_full_unstemmed MicroRNA Expression Profiling in PBMCs: A Potential Diagnostic Biomarker of Chronic Hepatitis C
title_short MicroRNA Expression Profiling in PBMCs: A Potential Diagnostic Biomarker of Chronic Hepatitis C
title_sort microrna expression profiling in pbmcs: a potential diagnostic biomarker of chronic hepatitis c
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255053/
https://www.ncbi.nlm.nih.gov/pubmed/25505813
http://dx.doi.org/10.1155/2014/367157
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