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Coexistence of Histologically Confirmed Hashimoto's Thyroiditis with Different Stages of Papillary Thyroid Carcinoma in a Consecutive Chinese Cohort

Purpose. To determine the relationship between Hashimoto's thyroiditis (HT) and all stages of papillary thyroid carcinoma (PTC) with or without local lymph node metastasis (LNM). Methods. We conducted a retrospective study of thyroidectomies from 2008–2013 in First Affiliated Hospital of Nanjin...

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Autores principales: Liu, Xiaoyun, Zhu, Lijun, Cui, Dai, Wang, Zhixiao, Chen, Huanhuan, Duan, Yu, Shen, Meiping, Wu, Yunsong, Rong, Rong, Zhang, Zhihong, Wang, Xiaodong, Chen, Jiawei, Alexander, Erik K., Yang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255062/
https://www.ncbi.nlm.nih.gov/pubmed/25505911
http://dx.doi.org/10.1155/2014/769294
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author Liu, Xiaoyun
Zhu, Lijun
Cui, Dai
Wang, Zhixiao
Chen, Huanhuan
Duan, Yu
Shen, Meiping
Wu, Yunsong
Rong, Rong
Zhang, Zhihong
Wang, Xiaodong
Chen, Jiawei
Alexander, Erik K.
Yang, Tao
author_facet Liu, Xiaoyun
Zhu, Lijun
Cui, Dai
Wang, Zhixiao
Chen, Huanhuan
Duan, Yu
Shen, Meiping
Wu, Yunsong
Rong, Rong
Zhang, Zhihong
Wang, Xiaodong
Chen, Jiawei
Alexander, Erik K.
Yang, Tao
author_sort Liu, Xiaoyun
collection PubMed
description Purpose. To determine the relationship between Hashimoto's thyroiditis (HT) and all stages of papillary thyroid carcinoma (PTC) with or without local lymph node metastasis (LNM). Methods. We conducted a retrospective study of thyroidectomies from 2008–2013 in First Affiliated Hospital of Nanjing Medical University. We categorized patients according to the presence of histopathologically proven HT. The prevalence of mPTC (maximum diameter ≤ 10 mm) and crPTC (clinical relevant PTC) and local LNM rates were compared. Results. We evaluated 6,432 consecutive thyroidectomies. In total, 1,328 specimens were confirmed as HT. The prevalence of PTC in this HT cohort was 43.8%, significantly higher than non-HT group. After adjustment of gender and age, the prevalence of PTC was still higher in HT group. HT was a risk factor for PTC in multivariate analysis with odds ratio 2.725 (95% CI, 2.390–3.109) (P < 0.001). However, no correlation was found between HT and LNM of PTC. Conclusion. HT was associated with an increased prevalence of all stages of PTC, independent of tumor size, gender, and age. In contrast, locally advanced disease defined by LNM was unrelated to HT. These data suggest an association of HT with low risk PTC and a potential protective immunologic effect from further disease progression.
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spelling pubmed-42550622014-12-11 Coexistence of Histologically Confirmed Hashimoto's Thyroiditis with Different Stages of Papillary Thyroid Carcinoma in a Consecutive Chinese Cohort Liu, Xiaoyun Zhu, Lijun Cui, Dai Wang, Zhixiao Chen, Huanhuan Duan, Yu Shen, Meiping Wu, Yunsong Rong, Rong Zhang, Zhihong Wang, Xiaodong Chen, Jiawei Alexander, Erik K. Yang, Tao Int J Endocrinol Research Article Purpose. To determine the relationship between Hashimoto's thyroiditis (HT) and all stages of papillary thyroid carcinoma (PTC) with or without local lymph node metastasis (LNM). Methods. We conducted a retrospective study of thyroidectomies from 2008–2013 in First Affiliated Hospital of Nanjing Medical University. We categorized patients according to the presence of histopathologically proven HT. The prevalence of mPTC (maximum diameter ≤ 10 mm) and crPTC (clinical relevant PTC) and local LNM rates were compared. Results. We evaluated 6,432 consecutive thyroidectomies. In total, 1,328 specimens were confirmed as HT. The prevalence of PTC in this HT cohort was 43.8%, significantly higher than non-HT group. After adjustment of gender and age, the prevalence of PTC was still higher in HT group. HT was a risk factor for PTC in multivariate analysis with odds ratio 2.725 (95% CI, 2.390–3.109) (P < 0.001). However, no correlation was found between HT and LNM of PTC. Conclusion. HT was associated with an increased prevalence of all stages of PTC, independent of tumor size, gender, and age. In contrast, locally advanced disease defined by LNM was unrelated to HT. These data suggest an association of HT with low risk PTC and a potential protective immunologic effect from further disease progression. Hindawi Publishing Corporation 2014 2014-11-18 /pmc/articles/PMC4255062/ /pubmed/25505911 http://dx.doi.org/10.1155/2014/769294 Text en Copyright © 2014 Xiaoyun Liu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Xiaoyun
Zhu, Lijun
Cui, Dai
Wang, Zhixiao
Chen, Huanhuan
Duan, Yu
Shen, Meiping
Wu, Yunsong
Rong, Rong
Zhang, Zhihong
Wang, Xiaodong
Chen, Jiawei
Alexander, Erik K.
Yang, Tao
Coexistence of Histologically Confirmed Hashimoto's Thyroiditis with Different Stages of Papillary Thyroid Carcinoma in a Consecutive Chinese Cohort
title Coexistence of Histologically Confirmed Hashimoto's Thyroiditis with Different Stages of Papillary Thyroid Carcinoma in a Consecutive Chinese Cohort
title_full Coexistence of Histologically Confirmed Hashimoto's Thyroiditis with Different Stages of Papillary Thyroid Carcinoma in a Consecutive Chinese Cohort
title_fullStr Coexistence of Histologically Confirmed Hashimoto's Thyroiditis with Different Stages of Papillary Thyroid Carcinoma in a Consecutive Chinese Cohort
title_full_unstemmed Coexistence of Histologically Confirmed Hashimoto's Thyroiditis with Different Stages of Papillary Thyroid Carcinoma in a Consecutive Chinese Cohort
title_short Coexistence of Histologically Confirmed Hashimoto's Thyroiditis with Different Stages of Papillary Thyroid Carcinoma in a Consecutive Chinese Cohort
title_sort coexistence of histologically confirmed hashimoto's thyroiditis with different stages of papillary thyroid carcinoma in a consecutive chinese cohort
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255062/
https://www.ncbi.nlm.nih.gov/pubmed/25505911
http://dx.doi.org/10.1155/2014/769294
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