Cargando…
Microfluidic preparation of polymer nanospheres
In this work, solid polymer nanospheres with their surface tailored for drug adhesion were prepared using a V-shaped microfluidic junction. The biocompatible polymer solutions were infused using two channels of the microfluidic junction which was also simultaneously fed with a volatile liquid, perfl...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255063/ https://www.ncbi.nlm.nih.gov/pubmed/25484617 http://dx.doi.org/10.1007/s11051-014-2626-5 |
_version_ | 1782347386567262208 |
---|---|
author | Kucuk, Israfil Edirisinghe, Mohan |
author_facet | Kucuk, Israfil Edirisinghe, Mohan |
author_sort | Kucuk, Israfil |
collection | PubMed |
description | In this work, solid polymer nanospheres with their surface tailored for drug adhesion were prepared using a V-shaped microfluidic junction. The biocompatible polymer solutions were infused using two channels of the microfluidic junction which was also simultaneously fed with a volatile liquid, perfluorohexane using the other channel. The mechanism by which the nanospheres are generated is explained using high speed camera imaging. The polymer concentration (5–50 wt%) and flow rates of the feeds (50–300 µl min(−1)) were important parameters in controlling the nanosphere diameter. The diameter of the polymer nanospheres was found to be in the range of 80–920 nm with a polydispersity index of 11–19 %. The interior structure and surfaces of the nanospheres prepared were studied using advanced microscopy and showed the presence of fine pores and cracks on surface which can be used as drug entrapment locations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11051-014-2626-5) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4255063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-42550632014-12-05 Microfluidic preparation of polymer nanospheres Kucuk, Israfil Edirisinghe, Mohan J Nanopart Res Research Paper In this work, solid polymer nanospheres with their surface tailored for drug adhesion were prepared using a V-shaped microfluidic junction. The biocompatible polymer solutions were infused using two channels of the microfluidic junction which was also simultaneously fed with a volatile liquid, perfluorohexane using the other channel. The mechanism by which the nanospheres are generated is explained using high speed camera imaging. The polymer concentration (5–50 wt%) and flow rates of the feeds (50–300 µl min(−1)) were important parameters in controlling the nanosphere diameter. The diameter of the polymer nanospheres was found to be in the range of 80–920 nm with a polydispersity index of 11–19 %. The interior structure and surfaces of the nanospheres prepared were studied using advanced microscopy and showed the presence of fine pores and cracks on surface which can be used as drug entrapment locations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11051-014-2626-5) contains supplementary material, which is available to authorized users. Springer Netherlands 2014-12-04 2014 /pmc/articles/PMC4255063/ /pubmed/25484617 http://dx.doi.org/10.1007/s11051-014-2626-5 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Research Paper Kucuk, Israfil Edirisinghe, Mohan Microfluidic preparation of polymer nanospheres |
title | Microfluidic preparation of polymer nanospheres |
title_full | Microfluidic preparation of polymer nanospheres |
title_fullStr | Microfluidic preparation of polymer nanospheres |
title_full_unstemmed | Microfluidic preparation of polymer nanospheres |
title_short | Microfluidic preparation of polymer nanospheres |
title_sort | microfluidic preparation of polymer nanospheres |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255063/ https://www.ncbi.nlm.nih.gov/pubmed/25484617 http://dx.doi.org/10.1007/s11051-014-2626-5 |
work_keys_str_mv | AT kucukisrafil microfluidicpreparationofpolymernanospheres AT edirisinghemohan microfluidicpreparationofpolymernanospheres |