Structural Identification of Modified Amino Acids on the Interface between EPO and Its Receptor from EPO BRP, Human Recombinant Erythropoietin by LC/MS Analysis

Protein modifications of recombinant pharmaceuticals have been observed both in vitro and in vivo. These modifications may result in lower efficacy, as well as bioavailability changes and antigenicity among the protein pharmaceuticals. Therefore, the contents of modification should be monitored for...

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Detalles Bibliográficos
Autores principales: Song, Kwang-Eun, Byeon, Jaehee, Moon, Dae-Bong, Kim, Hyong-Ha, Choi, Yoo-Joo, Suh, Jung-Keun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255102/
https://www.ncbi.nlm.nih.gov/pubmed/25284312
http://dx.doi.org/10.14348/molcells.2014.0214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255102/
https://www.ncbi.nlm.nih.gov/pubmed/25284312
http://dx.doi.org/10.14348/molcells.2014.0214

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