Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

MicroRNAs are small regulatory RNAs that post-transcriptionally control gene expression. Reduced expression of DICER, the enzyme involved in microRNA processing, is frequently observed in cancer and is associated with poor clinical outcome in various malignancies. Yet the underlying mechanisms are n...

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Detalles Bibliográficos
Autores principales: van den Beucken, Twan, Koch, Elizabeth, Chu, Kenneth, Rupaimoole, Rajesha, Prickaerts, Peggy, Adriaens, Michiel, Voncken, Jan Willem, Harris, Adrian L., Buffa, Francesca M., Haider, Syed, Starmans, Maud H.W., Yao, Cindy Q., Ivan, Mircea, Ivan, Cristina, Pecot, Chad V., Boutros, Paul C., Sood, Anil K., Koritzinsky, Marianne, Wouters, Bradly G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255228/
https://www.ncbi.nlm.nih.gov/pubmed/25351418
http://dx.doi.org/10.1038/ncomms6203

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