Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

Ischaemia-reperfusion (IR) injury occurs when blood supply to an organ is disrupted and then restored, and underlies many disorders, notably heart attack and stroke. While reperfusion of ischaemic tissue is essential for survival, it also initiates oxidative damage, cell death, and aberrant immune r...

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Detalles Bibliográficos
Autores principales: Chouchani, Edward T., Pell, Victoria R., Gaude, Edoardo, Aksentijević, Dunja, Sundier, Stephanie Y., Robb, Ellen L., Logan, Angela, Nadtochiy, Sergiy M., Ord, Emily N. J., Smith, Anthony C., Eyassu, Filmon, Shirley, Rachel, Hu, Chou-Hui, Dare, Anna J., James, Andrew M., Rogatti, Sebastian, Hartley, Richard C., Eaton, Simon, Costa, Ana S.H., Brookes, Paul S., Davidson, Sean M., Duchen, Michael R., Saeb-Parsy, Kourosh, Shattock, Michael J., Robinson, Alan J., Work, Lorraine M., Frezza, Christian, Krieg, Thomas, Murphy, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255242/
https://www.ncbi.nlm.nih.gov/pubmed/25383517
http://dx.doi.org/10.1038/nature13909

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