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Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours
The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of colorectal carcinoma. This traditional tumour staging summarizes data on tumour burden (T), the presence...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255306/ https://www.ncbi.nlm.nih.gov/pubmed/24122236 http://dx.doi.org/10.1002/path.4287 |
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author | Galon, Jérôme Mlecnik, Bernhard Bindea, Gabriela Angell, Helen K Berger, Anne Lagorce, Christine Lugli, Alessandro Zlobec, Inti Hartmann, Arndt Bifulco, Carlo Nagtegaal, Iris D Palmqvist, Richard Masucci, Giuseppe V Botti, Gerardo Tatangelo, Fabiana Delrio, Paolo Maio, Michele Laghi, Luigi Grizzi, Fabio Asslaber, Martin D'Arrigo, Corrado Vidal-Vanaclocha, Fernando Zavadova, Eva Chouchane, Lotfi Ohashi, Pamela S Hafezi-Bakhtiari, Sara Wouters, Bradly G Roehrl, Michael Nguyen, Linh Kawakami, Yutaka Hazama, Shoichi Okuno, Kiyotaka Ogino, Shuji Gibbs, Peter Waring, Paul Sato, Noriyuki Torigoe, Toshihiko Itoh, Kyogo Patel, Prabhu S Shukla, Shilin N Wang, Yili Kopetz, Scott Sinicrope, Frank A Scripcariu, Viorel Ascierto, Paolo A Marincola, Francesco M Fox, Bernard A Pagès, Franck |
author_facet | Galon, Jérôme Mlecnik, Bernhard Bindea, Gabriela Angell, Helen K Berger, Anne Lagorce, Christine Lugli, Alessandro Zlobec, Inti Hartmann, Arndt Bifulco, Carlo Nagtegaal, Iris D Palmqvist, Richard Masucci, Giuseppe V Botti, Gerardo Tatangelo, Fabiana Delrio, Paolo Maio, Michele Laghi, Luigi Grizzi, Fabio Asslaber, Martin D'Arrigo, Corrado Vidal-Vanaclocha, Fernando Zavadova, Eva Chouchane, Lotfi Ohashi, Pamela S Hafezi-Bakhtiari, Sara Wouters, Bradly G Roehrl, Michael Nguyen, Linh Kawakami, Yutaka Hazama, Shoichi Okuno, Kiyotaka Ogino, Shuji Gibbs, Peter Waring, Paul Sato, Noriyuki Torigoe, Toshihiko Itoh, Kyogo Patel, Prabhu S Shukla, Shilin N Wang, Yili Kopetz, Scott Sinicrope, Frank A Scripcariu, Viorel Ascierto, Paolo A Marincola, Francesco M Fox, Bernard A Pagès, Franck |
author_sort | Galon, Jérôme |
collection | PubMed |
description | The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of colorectal carcinoma. This traditional tumour staging summarizes data on tumour burden (T), the presence of cancer cells in draining and regional lymph nodes (N) and evidence for distant metastases (M). However, it is now recognized that the clinical outcome can vary significantly among patients within the same stage. The current classification provides limited prognostic information and does not predict response to therapy. Multiple ways to classify cancer and to distinguish different subtypes of colorectal cancer have been proposed, including morphology, cell origin, molecular pathways, mutation status and gene expression-based stratification. These parameters rely on tumour-cell characteristics. Extensive literature has investigated the host immune response against cancer and demonstrated the prognostic impact of the in situ immune cell infiltrate in tumours. A methodology named ‘Immunoscore’ has been defined to quantify the in situ immune infiltrate. In colorectal cancer, the Immunoscore may add to the significance of the current AJCC/UICC TNM classification, since it has been demonstrated to be a prognostic factor superior to the AJCC/UICC TNM classification. An international consortium has been initiated to validate and promote the Immunoscore in routine clinical settings. The results of this international consortium may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune). © 2013 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. |
format | Online Article Text |
id | pubmed-4255306 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42553062014-12-08 Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours Galon, Jérôme Mlecnik, Bernhard Bindea, Gabriela Angell, Helen K Berger, Anne Lagorce, Christine Lugli, Alessandro Zlobec, Inti Hartmann, Arndt Bifulco, Carlo Nagtegaal, Iris D Palmqvist, Richard Masucci, Giuseppe V Botti, Gerardo Tatangelo, Fabiana Delrio, Paolo Maio, Michele Laghi, Luigi Grizzi, Fabio Asslaber, Martin D'Arrigo, Corrado Vidal-Vanaclocha, Fernando Zavadova, Eva Chouchane, Lotfi Ohashi, Pamela S Hafezi-Bakhtiari, Sara Wouters, Bradly G Roehrl, Michael Nguyen, Linh Kawakami, Yutaka Hazama, Shoichi Okuno, Kiyotaka Ogino, Shuji Gibbs, Peter Waring, Paul Sato, Noriyuki Torigoe, Toshihiko Itoh, Kyogo Patel, Prabhu S Shukla, Shilin N Wang, Yili Kopetz, Scott Sinicrope, Frank A Scripcariu, Viorel Ascierto, Paolo A Marincola, Francesco M Fox, Bernard A Pagès, Franck J Pathol Invited Reviews The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of colorectal carcinoma. This traditional tumour staging summarizes data on tumour burden (T), the presence of cancer cells in draining and regional lymph nodes (N) and evidence for distant metastases (M). However, it is now recognized that the clinical outcome can vary significantly among patients within the same stage. The current classification provides limited prognostic information and does not predict response to therapy. Multiple ways to classify cancer and to distinguish different subtypes of colorectal cancer have been proposed, including morphology, cell origin, molecular pathways, mutation status and gene expression-based stratification. These parameters rely on tumour-cell characteristics. Extensive literature has investigated the host immune response against cancer and demonstrated the prognostic impact of the in situ immune cell infiltrate in tumours. A methodology named ‘Immunoscore’ has been defined to quantify the in situ immune infiltrate. In colorectal cancer, the Immunoscore may add to the significance of the current AJCC/UICC TNM classification, since it has been demonstrated to be a prognostic factor superior to the AJCC/UICC TNM classification. An international consortium has been initiated to validate and promote the Immunoscore in routine clinical settings. The results of this international consortium may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune). © 2013 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. John Wiley & Sons, Ltd 2014-01 2013-12-10 /pmc/articles/PMC4255306/ /pubmed/24122236 http://dx.doi.org/10.1002/path.4287 Text en © 2013 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Invited Reviews Galon, Jérôme Mlecnik, Bernhard Bindea, Gabriela Angell, Helen K Berger, Anne Lagorce, Christine Lugli, Alessandro Zlobec, Inti Hartmann, Arndt Bifulco, Carlo Nagtegaal, Iris D Palmqvist, Richard Masucci, Giuseppe V Botti, Gerardo Tatangelo, Fabiana Delrio, Paolo Maio, Michele Laghi, Luigi Grizzi, Fabio Asslaber, Martin D'Arrigo, Corrado Vidal-Vanaclocha, Fernando Zavadova, Eva Chouchane, Lotfi Ohashi, Pamela S Hafezi-Bakhtiari, Sara Wouters, Bradly G Roehrl, Michael Nguyen, Linh Kawakami, Yutaka Hazama, Shoichi Okuno, Kiyotaka Ogino, Shuji Gibbs, Peter Waring, Paul Sato, Noriyuki Torigoe, Toshihiko Itoh, Kyogo Patel, Prabhu S Shukla, Shilin N Wang, Yili Kopetz, Scott Sinicrope, Frank A Scripcariu, Viorel Ascierto, Paolo A Marincola, Francesco M Fox, Bernard A Pagès, Franck Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours |
title | Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours |
title_full | Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours |
title_fullStr | Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours |
title_full_unstemmed | Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours |
title_short | Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours |
title_sort | towards the introduction of the ‘immunoscore’ in the classification of malignant tumours |
topic | Invited Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255306/ https://www.ncbi.nlm.nih.gov/pubmed/24122236 http://dx.doi.org/10.1002/path.4287 |
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