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Lipids and cell death in yeast

Understanding lipid-induced malfunction represents a major challenge of today's biomedical research. The connection of lipids to cellular and organ dysfunction, cell death, and disease (often referred to as lipotoxicity) is more complex than the sole lipotoxic effects of excess free fatty acids...

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Detalles Bibliográficos
Autores principales: Eisenberg, Tobias, Büttner, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255311/
https://www.ncbi.nlm.nih.gov/pubmed/24119111
http://dx.doi.org/10.1111/1567-1364.12105
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author Eisenberg, Tobias
Büttner, Sabrina
author_facet Eisenberg, Tobias
Büttner, Sabrina
author_sort Eisenberg, Tobias
collection PubMed
description Understanding lipid-induced malfunction represents a major challenge of today's biomedical research. The connection of lipids to cellular and organ dysfunction, cell death, and disease (often referred to as lipotoxicity) is more complex than the sole lipotoxic effects of excess free fatty acids and requires genetically tractable model systems for mechanistic investigation. We herein summarize recent advances in the field of lipid-induced toxicity that employ the established model system for cell death and aging research of budding yeast Saccharomyces cerevisiae. Studies in yeast have shed light on various aspects of lipotoxicity, including free fatty acid toxicity, sphingolipid-modulated cell death as well as the involvement of cardiolipin and lipid peroxidation in the mitochondrial pathways of apoptosis. Regimens used range from exogenously applied lipids, genetic modulation of lipolysis and triacylglyceride synthesis, variations in sphingolipid/ceramide metabolism as well as changes in peroxisome function by either genetic or pharmacological means. In future, the yeast model of programmed cell death will further contribute to the clarification of crucial questions of lipid-associated malfunction.
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spelling pubmed-42553112014-12-08 Lipids and cell death in yeast Eisenberg, Tobias Büttner, Sabrina FEMS Yeast Res Minireviews Understanding lipid-induced malfunction represents a major challenge of today's biomedical research. The connection of lipids to cellular and organ dysfunction, cell death, and disease (often referred to as lipotoxicity) is more complex than the sole lipotoxic effects of excess free fatty acids and requires genetically tractable model systems for mechanistic investigation. We herein summarize recent advances in the field of lipid-induced toxicity that employ the established model system for cell death and aging research of budding yeast Saccharomyces cerevisiae. Studies in yeast have shed light on various aspects of lipotoxicity, including free fatty acid toxicity, sphingolipid-modulated cell death as well as the involvement of cardiolipin and lipid peroxidation in the mitochondrial pathways of apoptosis. Regimens used range from exogenously applied lipids, genetic modulation of lipolysis and triacylglyceride synthesis, variations in sphingolipid/ceramide metabolism as well as changes in peroxisome function by either genetic or pharmacological means. In future, the yeast model of programmed cell death will further contribute to the clarification of crucial questions of lipid-associated malfunction. Blackwell Publishing Ltd 2014-02 2013-10-30 /pmc/articles/PMC4255311/ /pubmed/24119111 http://dx.doi.org/10.1111/1567-1364.12105 Text en Copyright © 2014 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Minireviews
Eisenberg, Tobias
Büttner, Sabrina
Lipids and cell death in yeast
title Lipids and cell death in yeast
title_full Lipids and cell death in yeast
title_fullStr Lipids and cell death in yeast
title_full_unstemmed Lipids and cell death in yeast
title_short Lipids and cell death in yeast
title_sort lipids and cell death in yeast
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255311/
https://www.ncbi.nlm.nih.gov/pubmed/24119111
http://dx.doi.org/10.1111/1567-1364.12105
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