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Lipids and cell death in yeast
Understanding lipid-induced malfunction represents a major challenge of today's biomedical research. The connection of lipids to cellular and organ dysfunction, cell death, and disease (often referred to as lipotoxicity) is more complex than the sole lipotoxic effects of excess free fatty acids...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255311/ https://www.ncbi.nlm.nih.gov/pubmed/24119111 http://dx.doi.org/10.1111/1567-1364.12105 |
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author | Eisenberg, Tobias Büttner, Sabrina |
author_facet | Eisenberg, Tobias Büttner, Sabrina |
author_sort | Eisenberg, Tobias |
collection | PubMed |
description | Understanding lipid-induced malfunction represents a major challenge of today's biomedical research. The connection of lipids to cellular and organ dysfunction, cell death, and disease (often referred to as lipotoxicity) is more complex than the sole lipotoxic effects of excess free fatty acids and requires genetically tractable model systems for mechanistic investigation. We herein summarize recent advances in the field of lipid-induced toxicity that employ the established model system for cell death and aging research of budding yeast Saccharomyces cerevisiae. Studies in yeast have shed light on various aspects of lipotoxicity, including free fatty acid toxicity, sphingolipid-modulated cell death as well as the involvement of cardiolipin and lipid peroxidation in the mitochondrial pathways of apoptosis. Regimens used range from exogenously applied lipids, genetic modulation of lipolysis and triacylglyceride synthesis, variations in sphingolipid/ceramide metabolism as well as changes in peroxisome function by either genetic or pharmacological means. In future, the yeast model of programmed cell death will further contribute to the clarification of crucial questions of lipid-associated malfunction. |
format | Online Article Text |
id | pubmed-4255311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42553112014-12-08 Lipids and cell death in yeast Eisenberg, Tobias Büttner, Sabrina FEMS Yeast Res Minireviews Understanding lipid-induced malfunction represents a major challenge of today's biomedical research. The connection of lipids to cellular and organ dysfunction, cell death, and disease (often referred to as lipotoxicity) is more complex than the sole lipotoxic effects of excess free fatty acids and requires genetically tractable model systems for mechanistic investigation. We herein summarize recent advances in the field of lipid-induced toxicity that employ the established model system for cell death and aging research of budding yeast Saccharomyces cerevisiae. Studies in yeast have shed light on various aspects of lipotoxicity, including free fatty acid toxicity, sphingolipid-modulated cell death as well as the involvement of cardiolipin and lipid peroxidation in the mitochondrial pathways of apoptosis. Regimens used range from exogenously applied lipids, genetic modulation of lipolysis and triacylglyceride synthesis, variations in sphingolipid/ceramide metabolism as well as changes in peroxisome function by either genetic or pharmacological means. In future, the yeast model of programmed cell death will further contribute to the clarification of crucial questions of lipid-associated malfunction. Blackwell Publishing Ltd 2014-02 2013-10-30 /pmc/articles/PMC4255311/ /pubmed/24119111 http://dx.doi.org/10.1111/1567-1364.12105 Text en Copyright © 2014 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Minireviews Eisenberg, Tobias Büttner, Sabrina Lipids and cell death in yeast |
title | Lipids and cell death in yeast |
title_full | Lipids and cell death in yeast |
title_fullStr | Lipids and cell death in yeast |
title_full_unstemmed | Lipids and cell death in yeast |
title_short | Lipids and cell death in yeast |
title_sort | lipids and cell death in yeast |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255311/ https://www.ncbi.nlm.nih.gov/pubmed/24119111 http://dx.doi.org/10.1111/1567-1364.12105 |
work_keys_str_mv | AT eisenbergtobias lipidsandcelldeathinyeast AT buttnersabrina lipidsandcelldeathinyeast |