Cargando…

Imaging as a biomarker in drug discovery for Alzheimer’s disease: is MRI a suitable technology?

This review provides perspectives on the utility of magnetic resonance imaging (MRI) as a neuroimaging approach in the development of novel treatments for Alzheimer’s disease. These considerations were generated in a roundtable at a recent Wellcome Trust meeting that included experts from academia a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Merlo Pich, Emilio, Jeromin, Andreas, Frisoni, Giovanni B, Hill, Derek, Lockhart, Andrew, Schmidt, Mark E, Turner, Martin R, Mondello, Stefania, Potter, William Z
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255417/ https://www.ncbi.nlm.nih.gov/pubmed/25484927 http://dx.doi.org/10.1186/alzrt276

Ejemplares similares

Ubiquitin Carboxy-Terminal Hydrolase L1 (UCH-L1) is increased in cerebrospinal fluid and plasma of patients after epileptic seizure
por: Mondello, Stefania, et al.
Publicado: (2012)

Sex Differences in Circulating T-Tau Trajectories After Sports-Concussion and Correlation With Outcome
por: Mondello, Stefania, et al.
Publicado: (2020)

Orexin 1 receptor antagonists in compulsive behavior and anxiety: possible therapeutic use
por: Merlo Pich, Emilio, et al.
Publicado: (2014)

Ketamine enhances structural plasticity in human dopaminergic neurons: possible relevance for treatment-resistant depression
por: Collo, Ginetta, et al.
Publicado: (2018)

A human translational model based on neuroplasticity for pharmacological agents potentially effective in Treatment-Resistant Depression: focus on dopaminergic system
por: Collo, Ginetta, et al.
Publicado: (2019)

Advances in Cardiovascular Biomarker Discovery
por: Ghantous, Crystal M., et al.
Publicado: (2020)

CSF and Plasma Amyloid-β Temporal Profiles and Relationships with Neurological Status and Mortality after Severe Traumatic Brain Injury
por: Mondello, Stefania, et al.
Publicado: (2014)

Defining the purity of exosomes required for diagnostic profiling of small RNA suitable for biomarker discovery
por: Quek, Camelia, et al.
Publicado: (2016)

Early termination of pivotal trials in Alzheimer's disease—Preserving optimal value for participants and science
por: Gietl, Anton F., et al.
Publicado: (2022)

Structural Plasticity Induced by Ketamine in Human Dopaminergic Neurons as Mechanism Relevant for Treatment-Resistant Depression
por: Collo, Ginetta, et al.
Publicado: (2019)

Disclosure of Genetic Risk Factors for Alzheimer’s Disease to Cognitively Healthy Individuals—From Current Practice towards a Personalised Medicine Scenario
por: Galluzzi, Samantha, et al.
Publicado: (2022)

Towards an In Vitro Model of Plasmodium Hypnozoites Suitable for Drug Discovery
por: Dembele, Laurent, et al.
Publicado: (2011)

Electroencephalographic Rhythms in Alzheimer's Disease
por: Lizio, Roberta, et al.
Publicado: (2011)

Biomarker-based diagnosis of mild cognitive impairment due to Alzheimer’s disease: how and what to tell. A kickstart to an ethical discussion
por: Porteri, Corinna, et al.
Publicado: (2014)

To admit or not to admit? The suitability of critical care admission criteria
por: Marriott, D, et al.
Publicado: (2012)

Functional MRI technologies in the study of medication treatment effect on Alzheimer's disease
por: Guo, Hui, et al.
Publicado: (2018)

Functional MRI in Awake Dogs Predicts Suitability for Assistance Work
por: Berns, Gregory S., et al.
Publicado: (2017)

Optimal compressed sensing reconstructions of fMRI using 2D deterministic and stochastic sampling geometries
por: Jeromin, Oliver, et al.
Publicado: (2012)

The discovery of Alzheimer's disease
por: Hippius, Hanns, et al.
Publicado: (2003)

New Technologies for Discovery
por: Ahmed, Z., et al.
Publicado: (2019)

Anatomical Substrate and Scalp EEG Markers are Correlated in Subjects with Cognitive Impairment and Alzheimer's Disease
por: Moretti, Davide V., et al.
Publicado: (2011)

Comparison of the effects of transdermal and oral rivastigmine on cognitive function and EEG markers in patients with Alzheimer’s disease
por: Moretti, Davide V., et al.
Publicado: (2014)

Psychological Impact of Predictive Genetic Testing for Inherited Alzheimer Disease and Frontotemporal Dementia: The IT-DIAfN Protocol
por: Galluzzi, Samantha, et al.
Publicado: (2022)

Simulating the outcome of amyloid treatments in Alzheimer's disease from imaging and clinical data
por: Abi Nader, Clément, et al.
Publicado: (2021)

The Clinical Use of Alzheimer’s Disease Biomarkers in Patients with Mild Cognitive Impairment: A European Alzheimer’s Disease Consortium Survey
por: Caprioglio, Camilla, et al.
Publicado: (2022)

Wearable Devices for Assessing Function in Alzheimer's Disease: A European Public Involvement Activity About the Features and Preferences of Patients and Caregivers
por: Stavropoulos, Thanos G., et al.
Publicado: (2021)

Automated hippocampal segmentation in 3D MRI using random undersampling with boosting algorithm
por: Maglietta, Rosalia, et al.
Publicado: (2015)

BAALC expression: a suitable marker for prognostic risk stratification and detection of residual disease in cytogenetically normal acute myeloid leukemia
por: Weber, S, et al.
Publicado: (2014)

Multinuclear MRI in Drug Discovery
por: Bartusik-Aebisher, Dorota, et al.
Publicado: (2022)

A Comparative Analysis of Structural Brain MRI in the Diagnosis of Alzheimer’s Disease
por: Appel, Jason, et al.
Publicado: (2009)

Assessing the suitability of capillary electrophoresis‐mass spectrometry for biomarker discovery in plasma‐based metabolomics
por: Zhang, Wei, et al.
Publicado: (2019)

Negative Symptoms of Schizophrenia and Dopaminergic Transmission: Translational Models and Perspectives Opened by iPSC Techniques
por: Collo, Ginetta, et al.
Publicado: (2020)

Corrigendum: Negative Symptoms of Schizophrenia and Dopaminergic Transmission: Translational Models and Perspectives Opened by iPSC Techniques
por: Collo, Ginetta, et al.
Publicado: (2021)

VLP-Based Vaccines as a Suitable Technology to Target Trypanosomatid Diseases
por: Queiroz, Aline Maria Vasconcelos, et al.
Publicado: (2021)

Endoscopic Surveillance in Inflammatory Bowel Diseases: Selecting a Suitable Technology
por: Dal Buono, Arianna, et al.
Publicado: (2022)

Deficient Novelty Detection and Encoding in Early Alzheimer’s Disease: An ERP Study
por: Tautvydaitė, Domilė, et al.
Publicado: (2022)

Meeting report on the Alzheimer’s Drug Discovery Foundation 14th International Conference on Alzheimer’s Drug Discovery
por: Friedman, Lauren G, et al.
Publicado: (2014)

The pleiotropic role of p53 in functional/dysfunctional neurons: focus on pathogenesis and diagnosis of Alzheimer’s disease
por: Abate, Giulia, et al.
Publicado: (2020)

Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies
por: Lampe, John W., et al.
Publicado: (2021)

Open drug discovery in Alzheimer's disease
por: Axtman, Alison D., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ne34pjm9vbec1ca9drogjqpmg7