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Non-Canonical Notch Signaling in Cancer and Immunity

Canonical Notch signaling is initiated by γ-secretase-mediated cleavage of the Notch receptor, leading to the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-Jκ, resulting in the activation of downstream target genes. While canonical Notch sig...

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Detalles Bibliográficos
Autores principales:	Ayaz, Furkan, Osborne, Barbara A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255497/ https://www.ncbi.nlm.nih.gov/pubmed/25538890 http://dx.doi.org/10.3389/fonc.2014.00345

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