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DiI tracing of the hypothalamic projection systems during perinatal development

The hypothalamus is the higher neuroendocrine center of the brain and therefore possesses numerous intrinsic axonal connections and is connected by afferent and efferent fiber systems with other brain structures. These projection systems have been described in detail in the adult but data on their e...

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Autor principal: Makarenko, Irina G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255665/
https://www.ncbi.nlm.nih.gov/pubmed/25538571
http://dx.doi.org/10.3389/fnana.2014.00144
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author Makarenko, Irina G.
author_facet Makarenko, Irina G.
author_sort Makarenko, Irina G.
collection PubMed
description The hypothalamus is the higher neuroendocrine center of the brain and therefore possesses numerous intrinsic axonal connections and is connected by afferent and efferent fiber systems with other brain structures. These projection systems have been described in detail in the adult but data on their early development is sparse. Here I review studies of the time schedule and features of the development of the major hypothalamic axonal systems. In general, anterograde tracing experiments have been used to analyze short distance projections from the arcuate and anteroventral periventricular nuclei (Pe), while hypothalamic projections to the posterior and intermediate pituitary lobes (IL) and median eminence, mammillary body tracts and reciprocal septohypothalamic connections have been described with retrograde tracing. The available data demonstrate that hypothalamic connections develop with a high degree of spatial and temporal specificity, innervating each target with a unique developmental schedule which in many cases can be correlated with the functional maturity of the projection system.
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spelling pubmed-42556652014-12-23 DiI tracing of the hypothalamic projection systems during perinatal development Makarenko, Irina G. Front Neuroanat Neuroscience The hypothalamus is the higher neuroendocrine center of the brain and therefore possesses numerous intrinsic axonal connections and is connected by afferent and efferent fiber systems with other brain structures. These projection systems have been described in detail in the adult but data on their early development is sparse. Here I review studies of the time schedule and features of the development of the major hypothalamic axonal systems. In general, anterograde tracing experiments have been used to analyze short distance projections from the arcuate and anteroventral periventricular nuclei (Pe), while hypothalamic projections to the posterior and intermediate pituitary lobes (IL) and median eminence, mammillary body tracts and reciprocal septohypothalamic connections have been described with retrograde tracing. The available data demonstrate that hypothalamic connections develop with a high degree of spatial and temporal specificity, innervating each target with a unique developmental schedule which in many cases can be correlated with the functional maturity of the projection system. Frontiers Media S.A. 2014-12-04 /pmc/articles/PMC4255665/ /pubmed/25538571 http://dx.doi.org/10.3389/fnana.2014.00144 Text en Copyright © 2014 Makarenko. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Makarenko, Irina G.
DiI tracing of the hypothalamic projection systems during perinatal development
title DiI tracing of the hypothalamic projection systems during perinatal development
title_full DiI tracing of the hypothalamic projection systems during perinatal development
title_fullStr DiI tracing of the hypothalamic projection systems during perinatal development
title_full_unstemmed DiI tracing of the hypothalamic projection systems during perinatal development
title_short DiI tracing of the hypothalamic projection systems during perinatal development
title_sort dii tracing of the hypothalamic projection systems during perinatal development
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255665/
https://www.ncbi.nlm.nih.gov/pubmed/25538571
http://dx.doi.org/10.3389/fnana.2014.00144
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