Dissecting the Binding Mode of Low Affinity Phage Display Peptide Ligands to Protein Targets by Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry

[Image: see text] Phage display (PD) is frequently used to discover peptides capable of binding to biological protein targets. The structural characterization of peptide–protein complexes is often challenging due to their low binding affinities and high structural flexibility. Here, we investigate t...

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Detalles Bibliográficos
Autores principales: Leurs, Ulrike, Lohse, Brian, Ming, Shonoi, Cole, Philip A., Clausen, Rasmus P., Kristensen, Jesper L., Rand, Kasper D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255673/
https://www.ncbi.nlm.nih.gov/pubmed/25325890
http://dx.doi.org/10.1021/ac503137u

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