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Structural Analysis of a Novel Small Molecule Ligand Bound to the CXCL12 Chemokine
[Image: see text] CXCL12 binds to CXCR4, promoting both chemotaxis of lymphocytes and metastasis of cancer cells. We previously identified small molecule ligands that bind CXCL12 and block CXCR4-mediated chemotaxis. We now report a 1.9 Å resolution X-ray structure of CXCL12 bound by such a molecule...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255719/ https://www.ncbi.nlm.nih.gov/pubmed/25356720 http://dx.doi.org/10.1021/jm501194p |