Structure-Guided Development of Deoxycytidine Kinase Inhibitors with Nanomolar Affinity and Improved Metabolic Stability

[Image: see text] Recently, we have shown that small molecule dCK inhibitors in combination with pharmacological perturbations of de novo dNTP biosynthetic pathways could eliminate acute lymphoblastic leukemia cells in animal models. However, our previous lead compound had a short half-life in vivo....

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Detalles Bibliográficos
Autores principales: Nomme, Julian, Li, Zheng, Gipson, Raymond M., Wang, Jue, Armijo, Amanda L., Le, Thuc, Poddar, Soumya, Smith, Tony, Santarsiero, Bernard D., Nguyen, Hien-Anh, Czernin, Johannes, Alexandrova, Anastassia N., Jung, Michael E., Radu, Caius G., Lavie, Arnon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255734/
https://www.ncbi.nlm.nih.gov/pubmed/25341194
http://dx.doi.org/10.1021/jm501124j

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