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Intracranial Volume in 15 Children with Bilateral Coronal Craniosynostosis

BACKGROUND: Intracranial volume (ICV) growth in patients with bilateral coronal craniosynostosis (BCS) is not well described. It is therefore important to evaluate the consequences of cranial surgery in children with this condition. The aim of the present study was to evaluate ICVs in patients opera...

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Autores principales: Tovetjärn, Robert C. J., Maltese, Giovanni, Wikberg, Emma, Bernhardt, Peter, Kölby, Lars, Tarnow, Peter E. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255886/
https://www.ncbi.nlm.nih.gov/pubmed/25506526
http://dx.doi.org/10.1097/GOX.0000000000000216
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author Tovetjärn, Robert C. J.
Maltese, Giovanni
Wikberg, Emma
Bernhardt, Peter
Kölby, Lars
Tarnow, Peter E. W.
author_facet Tovetjärn, Robert C. J.
Maltese, Giovanni
Wikberg, Emma
Bernhardt, Peter
Kölby, Lars
Tarnow, Peter E. W.
author_sort Tovetjärn, Robert C. J.
collection PubMed
description BACKGROUND: Intracranial volume (ICV) growth in patients with bilateral coronal craniosynostosis (BCS) is not well described. It is therefore important to evaluate the consequences of cranial surgery in children with this condition. The aim of the present study was to evaluate ICVs in patients operated on for BCS. METHODS: A consecutive series of patients with BCS were operated on using spring-assisted cranioplasty, with computed tomography scans in 0.6-mm slices, were included. A MATLAB-based computer program capable of measuring ICV was used. Patients were compared with an age- and gender-matched control group of healthy children. Student’s t test was used for statistical analysis. RESULTS: Fifteen patients (7 girls and 8 boys) with 43 computed tomography scans were identified. The diagnoses were 13 syndromic BCS (3 Apert, 1 Crouzon, 6 Muenke, and 3 Saethre-Chotzen) and 2 nonsyndromic BCS. The mean preoperative volume at the age of 5 months (n = 15) was 887 mL (range, 687–1082). Mean volume at follow-up at the age of 3 years (n = 13) was 1369 mL (range, 1196–1616). In comparison, the mean ICVs for controls at the ages of 5 months (n = 30) and 3 years (n = 26) were 854 mL and 1358 mL, respectively. The differences were not statistically significant (P > 0.05). CONCLUSIONS: Patients with BCS were operated on with spring-assisted cranioplasty seem to maintain their age-related ICV at 3 years of age when compared to normal children.
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spelling pubmed-42558862014-12-12 Intracranial Volume in 15 Children with Bilateral Coronal Craniosynostosis Tovetjärn, Robert C. J. Maltese, Giovanni Wikberg, Emma Bernhardt, Peter Kölby, Lars Tarnow, Peter E. W. Plast Reconstr Surg Glob Open Original Articles BACKGROUND: Intracranial volume (ICV) growth in patients with bilateral coronal craniosynostosis (BCS) is not well described. It is therefore important to evaluate the consequences of cranial surgery in children with this condition. The aim of the present study was to evaluate ICVs in patients operated on for BCS. METHODS: A consecutive series of patients with BCS were operated on using spring-assisted cranioplasty, with computed tomography scans in 0.6-mm slices, were included. A MATLAB-based computer program capable of measuring ICV was used. Patients were compared with an age- and gender-matched control group of healthy children. Student’s t test was used for statistical analysis. RESULTS: Fifteen patients (7 girls and 8 boys) with 43 computed tomography scans were identified. The diagnoses were 13 syndromic BCS (3 Apert, 1 Crouzon, 6 Muenke, and 3 Saethre-Chotzen) and 2 nonsyndromic BCS. The mean preoperative volume at the age of 5 months (n = 15) was 887 mL (range, 687–1082). Mean volume at follow-up at the age of 3 years (n = 13) was 1369 mL (range, 1196–1616). In comparison, the mean ICVs for controls at the ages of 5 months (n = 30) and 3 years (n = 26) were 854 mL and 1358 mL, respectively. The differences were not statistically significant (P > 0.05). CONCLUSIONS: Patients with BCS were operated on with spring-assisted cranioplasty seem to maintain their age-related ICV at 3 years of age when compared to normal children. Wolters Kluwer Health 2014-12-05 /pmc/articles/PMC4255886/ /pubmed/25506526 http://dx.doi.org/10.1097/GOX.0000000000000216 Text en Copyright © 2014 The Authors. Published by Lippincott Williams & Wilkins on behalf of The American Society of Plastic Surgeons. PRS Global Open is a publication of the American Society of Plastic Surgeons. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Original Articles
Tovetjärn, Robert C. J.
Maltese, Giovanni
Wikberg, Emma
Bernhardt, Peter
Kölby, Lars
Tarnow, Peter E. W.
Intracranial Volume in 15 Children with Bilateral Coronal Craniosynostosis
title Intracranial Volume in 15 Children with Bilateral Coronal Craniosynostosis
title_full Intracranial Volume in 15 Children with Bilateral Coronal Craniosynostosis
title_fullStr Intracranial Volume in 15 Children with Bilateral Coronal Craniosynostosis
title_full_unstemmed Intracranial Volume in 15 Children with Bilateral Coronal Craniosynostosis
title_short Intracranial Volume in 15 Children with Bilateral Coronal Craniosynostosis
title_sort intracranial volume in 15 children with bilateral coronal craniosynostosis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255886/
https://www.ncbi.nlm.nih.gov/pubmed/25506526
http://dx.doi.org/10.1097/GOX.0000000000000216
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