Cargando…

Systems Medicine: from molecular features and models to the clinic in COPD

BACKGROUND AND HYPOTHESIS: Chronic Obstructive Pulmonary Disease (COPD) patients are characterized by heterogeneous clinical manifestations and patterns of disease progression. Two major factors that can be used to identify COPD subtypes are muscle dysfunction/wasting and co-morbidity patterns. We h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gomez-Cabrero, David, Menche, Jörg, Cano, Isaac, Abugessaisa, Imad, Huertas-Migueláñez, Mercedes, Tenyi, Akos, de Mas, Igor Marin, Kiani, Narsis A, Marabita, Francesco, Falciani, Francesco, Burrowes, Kelly, Maier, Dieter, Wagner, Peter, Selivanov, Vitaly, Cascante, Marta, Roca, Josep, Barabási, Albert-László, Tegnér, Jesper
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255907/ https://www.ncbi.nlm.nih.gov/pubmed/25471042 http://dx.doi.org/10.1186/1479-5876-12-S2-S4

Ejemplares similares

The COPD Knowledge Base: enabling data analysis and computational simulation in translational COPD research
por: Cano, Isaac, et al.
Publicado: (2014)

Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients
por: Tényi, Ákos, et al.
Publicado: (2018)

ChainRank, a chain prioritisation method for contextualisation of biological networks
por: Tényi, Ákos, et al.
Publicado: (2016)

Oxygen Pathway Modeling Estimates High Reactive Oxygen Species Production above the Highest Permanent Human Habitation
por: Cano, Isaac, et al.
Publicado: (2014)

Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management
por: Roca, Josep, et al.
Publicado: (2014)

From comorbidities of chronic obstructive pulmonary disease to identification of shared molecular mechanisms by data integration
por: Gomez-Cabrero, David, et al.
Publicado: (2016)

An Algorithmic Information Calculus for Causal Discovery and Reprogramming Systems
por: Zenil, Hector, et al.
Publicado: (2019)

A perspective on bridging scales and design of models using low-dimensional manifolds and data-driven model inference
por: Tegnér, Jesper, et al.
Publicado: (2016)

Implementation of the CDC translational informatics platform - from genetic variants to the national Swedish Rheumatology Quality Register
por: Abugessaisa, Imad, et al.
Publicado: (2013)

STATegra EMS: an Experiment Management System for complex next-generation omics experiments
por: Hernández-de-Diego, Rafael, et al.
Publicado: (2014)

Biomedical research in a Digital Health Framework
por: Cano, Isaac, et al.
Publicado: (2014)

A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data
por: Teschendorff, Andrew E., et al.
Publicado: (2013)

Predictive medicine: outcomes, challenges and opportunities in the Synergy-COPD project
por: Miralles, Felip, et al.
Publicado: (2014)

Synergy-COPD: a systems approach for understanding and managing chronic diseases
por: Gomez-Cabrero, David, et al.
Publicado: (2014)

Symmetry and Correspondence of Algorithmic Complexity over Geometric, Spatial and Topological Representations †
por: Zenil, Hector, et al.
Publicado: (2018)

A Review of Graph and Network Complexity from an Algorithmic Information Perspective
por: Zenil, Hector, et al.
Publicado: (2018)

The Thermodynamics of Network Coding, and an Algorithmic Refinement of the Principle of Maximum Entropy †
por: Zenil, Hector, et al.
Publicado: (2019)

Data integration in the era of omics: current and future challenges
por: Gomez-Cabrero, David, et al.
Publicado: (2014)

Simulation environment and graphical visualization environment: a COPD use-case
por: Huertas-Migueláñez, Mercedes, et al.
Publicado: (2014)

An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training
por: Lindholm, Maléne E, et al.
Publicado: (2014)

Conditional Disease Development extracted from Longitudinal Health Care Cohort Data using Layered Network Construction
por: Kannan, Venkateshan, et al.
Publicado: (2016)

Risk and temporal order of disease diagnosis of comorbidities in patients with COPD: a population health perspective
por: Tényi, Ákos, et al.
Publicado: (2018)

Phosphatase inhibitor PPP1R11 modulates resistance of human T cells toward Treg‐mediated suppression of cytokine expression
por: Joshi, Rubin N., et al.
Publicado: (2019)

Compartmentation of glycogen metabolism revealed from (13)C isotopologue distributions
por: Marin de Mas, Igor, et al.
Publicado: (2011)

Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3
por: Schmidt, Angelika, et al.
Publicado: (2018)

scAEGAN: Unification of single-cell genomics data by adversarial learning of latent space correspondences
por: Khan, Sumeer Ahmad, et al.
Publicado: (2023)

Normalization of circulating microRNA expression data obtained by quantitative real-time RT-PCR
por: Marabita, Francesco, et al.
Publicado: (2016)

Algorithmic Probability-Guided Machine Learning on Non-Differentiable Spaces
por: Hernández-Orozco, Santiago, et al.
Publicado: (2021)

MYC as a driver of stochastic chromatin networks: implications for the fitness of cancer cells
por: Sumida, Noriyuki, et al.
Publicado: (2020)

The Role of External and Matrix pH in Mitochondrial Reactive Oxygen Species Generation
por: Selivanov, Vitaly A., et al.
Publicado: (2008)

Bistability of Mitochondrial Respiration Underlies Paradoxical Reactive Oxygen Species Generation Induced by Anoxia
por: Selivanov, Vitaly A., et al.
Publicado: (2009)

An evaluation of analysis pipelines for DNA methylation profiling using the Illumina HumanMethylation450 BeadChip platform
por: Marabita, Francesco, et al.
Publicado: (2013)

A Decomposition Method for Global Evaluation of Shannon Entropy and Local Estimations of Algorithmic Complexity
por: Zenil, Hector, et al.
Publicado: (2018)

Knowledge management for systems biology a general and visually driven framework applied to translational medicine
por: Maier, Dieter, et al.
Publicado: (2011)

Immunometabolic Network Interactions of the Kynurenine Pathway in Cutaneous Malignant Melanoma
por: Rad Pour, Soudabeh, et al.
Publicado: (2020)

Accelerating Translational Research by Clinically Driven Development of an Informatics Platform–A Case Study
por: Abugessaisa, Imad, et al.
Publicado: (2014)

Unveiling a key role of oxaloacetate-glutamate interaction in regulation of respiration and ROS generation in nonsynaptic brain mitochondria using a kinetic model
por: Selivanov, Vitaly A., et al.
Publicado: (2021)

Reactive Oxygen Species Production by Forward and Reverse Electron Fluxes in the Mitochondrial Respiratory Chain
por: Selivanov, Vitaly A., et al.
Publicado: (2011)

Phosphoproteomics Reveals Regulatory T Cell-Mediated DEF6 Dephosphorylation That Affects Cytokine Expression in Human Conventional T Cells
por: Joshi, Rubin N., et al.
Publicado: (2017)

Workforce preparation: the Biohealth computing model for Master and PhD students
por: Cascante, Marta, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_9mblj599i2tlugp8fvhho8uvuj