Sulindac derivatives inhibit cell growth and induce apoptosis in primary cells from malignant peripheral nerve sheath tumors of NF1-patients

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNSTs) are neoplasms leading to death in most cases. Patients with Neurofibromatosis type 1 have an increased risk of developing this malignancy. The metabolites of the inactive prodrug Sulindac, Sulindac Sulfide and Sulindac Sulfone (Exisulind)...

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Detalles Bibliográficos
Autores principales: Frahm, Silke, Kurtz, Andreas, Kluwe, Lan, Farassati, Faris, Friedrich, Reinhard E, Mautner, Victor F
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC425591/
https://www.ncbi.nlm.nih.gov/pubmed/15147581
http://dx.doi.org/10.1186/1475-2867-4-4

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