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The Long-Term Outcomes of Induction Chemoradiotherapy Followed by Surgery for Locally Advanced Non-Small Cell Lung Cancer
BACKGROUND: Although the concept of induction therapy followed by surgical resection for locally advanced non-small cell lung cancer (LA-NSCLC) has found general acceptance, the appropriate indications and the strategy for this treatment are still controversial. METHODS: From 2000 through 2008, 36 p...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255996/ https://www.ncbi.nlm.nih.gov/pubmed/25493083 http://dx.doi.org/10.1159/000368598 |
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author | Uramoto, Hidetaka Akiyama, Hirohiko Nakajima, Yuki Kinoshita, Hiroyasu Inoue, Takuya Kurimoto, Futoshi Nishimura, Yu Saito, Yoshihiro Sakai, Hiroshi Kobayashi, Kunihiko |
author_facet | Uramoto, Hidetaka Akiyama, Hirohiko Nakajima, Yuki Kinoshita, Hiroyasu Inoue, Takuya Kurimoto, Futoshi Nishimura, Yu Saito, Yoshihiro Sakai, Hiroshi Kobayashi, Kunihiko |
author_sort | Uramoto, Hidetaka |
collection | PubMed |
description | BACKGROUND: Although the concept of induction therapy followed by surgical resection for locally advanced non-small cell lung cancer (LA-NSCLC) has found general acceptance, the appropriate indications and the strategy for this treatment are still controversial. METHODS: From 2000 through 2008, 36 patients received concurrent chemoradiotherapy followed by surgery. We retrospectively reviewed these cases, analyzed the outcomes and examined the prognosis. RESULTS: The median radiation dose given was 60 Gy. Chemotherapy included a platinum agent in all cases; cisplatin-based chemotherapy was administered to 9 cases, and a carboplatin-based chemotherapy regimen was administered to 27. A complete resection was performed in 94% of the patients. Seventeen (47.2%) patients exhibited a complete pathological response, and downstaging was induced in 26 (72%) cases. The morbidity and 30-day mortality rates were 11.1 and 0%, respectively. The 5-year overall survival rate in the patients with complete resection (n = 33) was 83.3%. CONCLUSIONS: Induction chemoradiotherapy followed by surgery for LA-NSCLC provided a favorable prognosis for selected patients. A complete pathological response was found in about half of cases. This strategy is feasible and was associated with low morbidity and high resectability rates, suggesting that it contributed to improving the treatment results. |
format | Online Article Text |
id | pubmed-4255996 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-42559962014-12-09 The Long-Term Outcomes of Induction Chemoradiotherapy Followed by Surgery for Locally Advanced Non-Small Cell Lung Cancer Uramoto, Hidetaka Akiyama, Hirohiko Nakajima, Yuki Kinoshita, Hiroyasu Inoue, Takuya Kurimoto, Futoshi Nishimura, Yu Saito, Yoshihiro Sakai, Hiroshi Kobayashi, Kunihiko Case Rep Oncol Published online: October, 2014 BACKGROUND: Although the concept of induction therapy followed by surgical resection for locally advanced non-small cell lung cancer (LA-NSCLC) has found general acceptance, the appropriate indications and the strategy for this treatment are still controversial. METHODS: From 2000 through 2008, 36 patients received concurrent chemoradiotherapy followed by surgery. We retrospectively reviewed these cases, analyzed the outcomes and examined the prognosis. RESULTS: The median radiation dose given was 60 Gy. Chemotherapy included a platinum agent in all cases; cisplatin-based chemotherapy was administered to 9 cases, and a carboplatin-based chemotherapy regimen was administered to 27. A complete resection was performed in 94% of the patients. Seventeen (47.2%) patients exhibited a complete pathological response, and downstaging was induced in 26 (72%) cases. The morbidity and 30-day mortality rates were 11.1 and 0%, respectively. The 5-year overall survival rate in the patients with complete resection (n = 33) was 83.3%. CONCLUSIONS: Induction chemoradiotherapy followed by surgery for LA-NSCLC provided a favorable prognosis for selected patients. A complete pathological response was found in about half of cases. This strategy is feasible and was associated with low morbidity and high resectability rates, suggesting that it contributed to improving the treatment results. S. Karger AG 2014-10-23 /pmc/articles/PMC4255996/ /pubmed/25493083 http://dx.doi.org/10.1159/000368598 Text en Copyright © 2014 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published online: October, 2014 Uramoto, Hidetaka Akiyama, Hirohiko Nakajima, Yuki Kinoshita, Hiroyasu Inoue, Takuya Kurimoto, Futoshi Nishimura, Yu Saito, Yoshihiro Sakai, Hiroshi Kobayashi, Kunihiko The Long-Term Outcomes of Induction Chemoradiotherapy Followed by Surgery for Locally Advanced Non-Small Cell Lung Cancer |
title | The Long-Term Outcomes of Induction Chemoradiotherapy Followed by Surgery for Locally Advanced Non-Small Cell Lung Cancer |
title_full | The Long-Term Outcomes of Induction Chemoradiotherapy Followed by Surgery for Locally Advanced Non-Small Cell Lung Cancer |
title_fullStr | The Long-Term Outcomes of Induction Chemoradiotherapy Followed by Surgery for Locally Advanced Non-Small Cell Lung Cancer |
title_full_unstemmed | The Long-Term Outcomes of Induction Chemoradiotherapy Followed by Surgery for Locally Advanced Non-Small Cell Lung Cancer |
title_short | The Long-Term Outcomes of Induction Chemoradiotherapy Followed by Surgery for Locally Advanced Non-Small Cell Lung Cancer |
title_sort | long-term outcomes of induction chemoradiotherapy followed by surgery for locally advanced non-small cell lung cancer |
topic | Published online: October, 2014 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255996/ https://www.ncbi.nlm.nih.gov/pubmed/25493083 http://dx.doi.org/10.1159/000368598 |
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