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Ribes fasciculatum var. chinense Attenuated Allergic Inflammation In Vivo and In Vitro
Ribes fasciculatum var. chinense MAX. (R. fasciculatum) has traditionally been used in Korea to treat inflammatory diseases. However, the exact mechanism that accounts for the anti-inflammatory effect of R. fasciculatum is not completely understood. We aimed to ascertain the pharmacological effects...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Applied Pharmacology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256035/ https://www.ncbi.nlm.nih.gov/pubmed/25489423 http://dx.doi.org/10.4062/biomolther.2014.015 |
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author | Jung, Ji-Wook Kim, Su-Jin Ahn, Eun-Mi Oh, Sa-Rang Lee, Hye-Ja Jeong, Ji-Ahn Lee, Ju-Young |
author_facet | Jung, Ji-Wook Kim, Su-Jin Ahn, Eun-Mi Oh, Sa-Rang Lee, Hye-Ja Jeong, Ji-Ahn Lee, Ju-Young |
author_sort | Jung, Ji-Wook |
collection | PubMed |
description | Ribes fasciculatum var. chinense MAX. (R. fasciculatum) has traditionally been used in Korea to treat inflammatory diseases. However, the exact mechanism that accounts for the anti-inflammatory effect of R. fasciculatum is not completely understood. We aimed to ascertain the pharmacological effects of R. fasciculatum on both compound 48/80- or histamine-induced scratching behaviors and 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice. Additionally, to find a possible explanation for the anti-inflammatory effects of R. fasciculatum, we evaluated the effects of R. fasciculatum on the production of inflammatory mediators in LPS-stimulated macrophage cells. Treatment of R. fasciculatum significantly reduced compound 48/80- or histamine-induced the pruritus in mice. R. fasciculatum attenuated the AD symptoms such as eczematous, erythema and dryness and serum IgE levels in AD model. Additionally, R. fasciculatum inhibited the production of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). The maximal rates of TNF-α and IL-6 inhibition by R. fasciculatum (1 mg/ml) were approximately 32.12% and 46.24%, respectively. We also showed that R. fasciculatum inhibited the activation of nuclear factor-kappa B in LPS-stimulated macrophages. Collectively, the findings of this study provide us with novel insights into the pharmacological actions of R. fasciculatum as a potential molecule for use in the treatment of allergic inflammatory diseases. |
format | Online Article Text |
id | pubmed-4256035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Korean Society of Applied Pharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-42560352014-12-08 Ribes fasciculatum var. chinense Attenuated Allergic Inflammation In Vivo and In Vitro Jung, Ji-Wook Kim, Su-Jin Ahn, Eun-Mi Oh, Sa-Rang Lee, Hye-Ja Jeong, Ji-Ahn Lee, Ju-Young Biomol Ther (Seoul) Original Article Ribes fasciculatum var. chinense MAX. (R. fasciculatum) has traditionally been used in Korea to treat inflammatory diseases. However, the exact mechanism that accounts for the anti-inflammatory effect of R. fasciculatum is not completely understood. We aimed to ascertain the pharmacological effects of R. fasciculatum on both compound 48/80- or histamine-induced scratching behaviors and 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice. Additionally, to find a possible explanation for the anti-inflammatory effects of R. fasciculatum, we evaluated the effects of R. fasciculatum on the production of inflammatory mediators in LPS-stimulated macrophage cells. Treatment of R. fasciculatum significantly reduced compound 48/80- or histamine-induced the pruritus in mice. R. fasciculatum attenuated the AD symptoms such as eczematous, erythema and dryness and serum IgE levels in AD model. Additionally, R. fasciculatum inhibited the production of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). The maximal rates of TNF-α and IL-6 inhibition by R. fasciculatum (1 mg/ml) were approximately 32.12% and 46.24%, respectively. We also showed that R. fasciculatum inhibited the activation of nuclear factor-kappa B in LPS-stimulated macrophages. Collectively, the findings of this study provide us with novel insights into the pharmacological actions of R. fasciculatum as a potential molecule for use in the treatment of allergic inflammatory diseases. The Korean Society of Applied Pharmacology 2014-11 2014-11-30 /pmc/articles/PMC4256035/ /pubmed/25489423 http://dx.doi.org/10.4062/biomolther.2014.015 Text en Copyright ©2014, The Korean Society of Applied Pharmacology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jung, Ji-Wook Kim, Su-Jin Ahn, Eun-Mi Oh, Sa-Rang Lee, Hye-Ja Jeong, Ji-Ahn Lee, Ju-Young Ribes fasciculatum var. chinense Attenuated Allergic Inflammation In Vivo and In Vitro |
title | Ribes fasciculatum var. chinense Attenuated Allergic Inflammation In Vivo and In Vitro |
title_full | Ribes fasciculatum var. chinense Attenuated Allergic Inflammation In Vivo and In Vitro |
title_fullStr | Ribes fasciculatum var. chinense Attenuated Allergic Inflammation In Vivo and In Vitro |
title_full_unstemmed | Ribes fasciculatum var. chinense Attenuated Allergic Inflammation In Vivo and In Vitro |
title_short | Ribes fasciculatum var. chinense Attenuated Allergic Inflammation In Vivo and In Vitro |
title_sort | ribes fasciculatum var. chinense attenuated allergic inflammation in vivo and in vitro |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256035/ https://www.ncbi.nlm.nih.gov/pubmed/25489423 http://dx.doi.org/10.4062/biomolther.2014.015 |
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