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Dependence Potential of Tramadol: Behavioral Pharmacology in Rodents

Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability...

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Detalles Bibliográficos
Autores principales: Cha, Hye Jin, Song, Min Ji, Lee, Kwang-Wook, Kim, Eun Jung, Kim, Young-Hoon, Lee, Yunje, Seong, Won-Keun, Hong, Sa-Ik, Jang, Choon-Gon, Yoo, Han Sang, Jeong, Ho-Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256037/
https://www.ncbi.nlm.nih.gov/pubmed/25489425
http://dx.doi.org/10.4062/biomolther.2014.064
Descripción
Sumario:Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.