Cargando…

Anti-tat Hutat2:Fc mediated protection against tat-induced neurotoxicity and HIV-1 replication in human monocyte-derived macrophages

BACKGROUND: HIV-1 Tat is essential for HIV replication and is also a well-known neurotoxic factor causing HIV-associated neurocognitive disorder (HAND). Currently, combined antiretroviral therapy targeting HIV reverse transcriptase or protease cannot prevent the production of early viral proteins, e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kang, Wen, Marasco, Wayne A, Tong, Hsin-I, Byron, Mary Margaret, Wu, Chengxiang, Shi, Yingli, Sun, Si, Sun, Yongtao, Lu, Yuanan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256057/ https://www.ncbi.nlm.nih.gov/pubmed/25416164 http://dx.doi.org/10.1186/s12974-014-0195-2

Ejemplares similares

Generation of Hutat2:Fc Knockin Primary Human Monocytes Using CRISPR/Cas9
por: Wang, Bowen, et al.
Publicado: (2018)

Role of endolysosomes in HIV-1 Tat-induced neurotoxicity
por: Hui, Liang, et al.
Publicado: (2012)

Neurotoxicity of HIV-1 Tat is attributed to its penetrating property
por: Tang, Xiaoli, et al.
Publicado: (2020)

TatBC-Independent TatA/Tat Substrate Interactions Contribute to Transport Efficiency
por: Taubert, Johannes, et al.
Publicado: (2015)

How to achieve Tat transport with alien TatA
por: Hauer, René Steffen, et al.
Publicado: (2017)

Substrate-triggered position switching of TatA and TatB during Tat transport in Escherichia coli
por: Habersetzer, Johann, et al.
Publicado: (2017)

Comparative Analysis of Tat-Dependent and Tat-Deficient Natural Lentiviruses
por: Bose, Deepanwita, et al.
Publicado: (2015)

TatA and TatB generate a hydrophobic mismatch important for the function and assembly of the Tat translocon in Escherichia coli
por: Mehner-Breitfeld, Denise, et al.
Publicado: (2022)

Oxidative Stress Is Associated with Neuroinflammation in Animal Models of HIV-1 Tat Neurotoxicity
por: Louboutin, Jean-Pierre, et al.
Publicado: (2014)

Characterization of a TatA/TatB binding site on the TatC component of the Escherichia coli twin arginine translocase
por: Severi, Emmanuele, et al.
Publicado: (2023)

A reversal of Tat
por: Tuma, Rabiya S.
Publicado: (2005)

The two sides of Tat
por: Barboric, Matjaz, et al.
Publicado: (2016)

Potent Inhibition of HIV-1 Replication by a Tat Mutant
por: Meredith, Luke W., et al.
Publicado: (2009)

HEXIM1-Tat chimera inhibits HIV-1 replication
por: Leoz, Marie, et al.
Publicado: (2018)

Blockade of monocyte-endothelial trafficking by transduced Tat-superoxide dismutase protein
por: PARK, SIN-HYE, et al.
Publicado: (2016)

TatB Functions as an Oligomeric Binding Site for Folded Tat Precursor Proteins
por: Maurer, Carlo, et al.
Publicado: (2010)

Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein
por: Charnay, Nicolas, et al.
Publicado: (2009)

Molecular dissection of TatC defines critical regions essential for protein transport and a TatB–TatC contact site
por: Kneuper, Holger, et al.
Publicado: (2012)

A monoclonal antibody against HIV Tat attenuates neurotoxicity via glutamate receptors
por: Rumbaugh, Jeffrey, et al.
Publicado: (2006)

HIV-Tat protein and amyloid β peptide form multifibrillar structures that cause neurotoxicity
por: Hategan, Alina, et al.
Publicado: (2017)

Strong In Vivo Inhibition of HIV-1 Replication by Nullbasic, a Tat Mutant
por: Jin, Hongping, et al.
Publicado: (2019)

TatBC, TatB, and TatC form structurally autonomous units within the twin arginine protein transport system of Escherichia coli
por: Orriss, George L., et al.
Publicado: (2007)

Unanticipated functional diversity among the TatA-type components of the Tat protein translocase
por: Eimer, Ekaterina, et al.
Publicado: (2018)

New insights into the Tat protein transport cycle from characterizing the assembled Tat translocon
por: Alcock, Felicity, et al.
Publicado: (2022)

Genetic Evidence for a Tight Cooperation of TatB and TatC during Productive Recognition of Twin-Arginine (Tat) Signal Peptides in Escherichia coli
por: Lausberg, Frank, et al.
Publicado: (2012)

Potent suppression of HIV viral replication by a novel inhibitor of Tat
por: Mousseau, Guillaume, et al.
Publicado: (2012)

HIV-1 Tat Protein Increases Microglial Outward K(+) Current and Resultant Neurotoxic Activity
por: Liu, Jianuo, et al.
Publicado: (2013)

Astrocytic metabolic switch is a novel etiology for Cocaine and HIV-1 Tat-mediated neurotoxicity
por: Natarajaseenivasan, Kalimuthusamy, et al.
Publicado: (2018)

The lncRNA LOC102549805 (U1) modulates neurotoxicity of HIV-1 Tat protein
por: Torkzaban, Bahareh, et al.
Publicado: (2020)

Iron Saturation Drives Lactoferrin Effects on Oxidative Stress and Neurotoxicity Induced by HIV-1 Tat
por: Ianiro, Giusi, et al.
Publicado: (2023)

Tat substrates open the portal
por: Short, Ben
Publicado: (2014)

Sec and Tat share the workload
por: Short, Ben
Publicado: (2012)

Assembling the Tat protein translocase
por: Alcock, Felicity, et al.
Publicado: (2016)

The Tat and Cat in Clinical Use
por: Franks, Cyril M.
Publicado: (1955)

From ESMO TAT 2021
por: Killock, David
Publicado: (2021)

NUCKS1, a novel Tat coactivator, plays a crucial role in HIV-1 replication by increasing Tat-mediated viral transcription on the HIV-1 LTR promoter
por: Kim, Hye-Young, et al.
Publicado: (2014)

Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat
por: Egelé, Caroline, et al.
Publicado: (2008)

Dynamic interactions of the HIV-1 Tat with nucleic acids are critical for Tat activity in reverse transcription
por: Boudier, Christian, et al.
Publicado: (2014)

Twin-Arginine Translocation System in Helicobacter pylori: TatC, but Not TatB, Is Essential for Viability
por: Benoit, Stéphane L., et al.
Publicado: (2014)

Transmembrane insertion of twin-arginine signal peptides is driven by TatC and regulated by TatB
por: Fröbel, Julia, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_58esm7m95ale71go8upj14dt10