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Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway

Inactivation of cell survival factors is a crucial step in apoptosis. The phosphoinositide 3 kinase (PI3K) and AKT signaling pathway promotes cell growth, proliferation and survival and its deregulation causes cancer. How this pathway is suppressed to promote apoptosis is poorly understood. Here we...

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Detalles Bibliográficos
Autores principales:	Nakagawa, Akihisa, Sullivan, Kelly D., Xue, Ding
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256149/ https://www.ncbi.nlm.nih.gov/pubmed/25383666 http://dx.doi.org/10.1038/nsmb.2915

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