Ectopic MicroRNA-150-5p Transcription Sensitizes Glucocorticoid Therapy Response in MM1S Multiple Myeloma Cells but Fails to Overcome Hormone Therapy Resistance in MM1R Cells

Glucocorticoids (GCs) selectively trigger cell death in the multiple myeloma cell line MM1S which express NR3C1/Glucocorticoid Receptor (GR) protein, but fail to kill MM1R cells which lack GR protein. Given recent demonstrations of altered microRNA profiles in a diverse range of haematological malig...

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Detalles Bibliográficos
Autores principales: Palagani, Ajay, Op de Beeck, Ken, Naulaerts, Stefan, Diddens, Jolien, Sekhar Chirumamilla, Chandra, Van Camp, Guy, Laukens, Kris, Heyninck, Karen, Gerlo, Sarah, Mestdagh, Pieter, Vandesompele, Joke, Berghe, Wim Vanden
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256227/
https://www.ncbi.nlm.nih.gov/pubmed/25474406
http://dx.doi.org/10.1371/journal.pone.0113842

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