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Profound Activity of the Anti-cancer Drug Bortezomib against Echinococcus multilocularis Metacestodes Identifies the Proteasome as a Novel Drug Target for Cestodes

A library of 426 FDA-approved drugs was screened for in vitro activity against E. multilocularis metacestodes employing the phosphoglucose isomerase (PGI) assay. Initial screening at 20 µM revealed that 7 drugs induced considerable metacestode damage, and further dose-response studies revealed that...

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Detalles Bibliográficos
Autores principales:	Stadelmann, Britta, Aeschbacher, Denise, Huber, Cristina, Spiliotis, Markus, Müller, Joachim, Hemphill, Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256282/ https://www.ncbi.nlm.nih.gov/pubmed/25474446 http://dx.doi.org/10.1371/journal.pntd.0003352

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