Cargando…
Profound Activity of the Anti-cancer Drug Bortezomib against Echinococcus multilocularis Metacestodes Identifies the Proteasome as a Novel Drug Target for Cestodes
A library of 426 FDA-approved drugs was screened for in vitro activity against E. multilocularis metacestodes employing the phosphoglucose isomerase (PGI) assay. Initial screening at 20 µM revealed that 7 drugs induced considerable metacestode damage, and further dose-response studies revealed that...
Autores principales: | Stadelmann, Britta, Aeschbacher, Denise, Huber, Cristina, Spiliotis, Markus, Müller, Joachim, Hemphill, Andrew |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256282/ https://www.ncbi.nlm.nih.gov/pubmed/25474446 http://dx.doi.org/10.1371/journal.pntd.0003352 |
Ejemplares similares
-
In vitro metabolomic footprint of the Echinococcus multilocularis metacestode
por: Ritler, Dominic, et al.
Publicado: (2019) -
Author Correction: In vitro metabolomic footprint of the Echinococcus multilocularis metacestode
por: Ritler, Dominic, et al.
Publicado: (2021) -
Targeted and non-targeted proteomics to characterize the parasite proteins of Echinococcus multilocularis metacestodes
por: Müller, Joachim, et al.
Publicado: (2023) -
Drug repurposing applied: Activity of the anti-malarial mefloquine against Echinococcus multilocularis
por: Lundström-Stadelmann, Britta, et al.
Publicado: (2020) -
Transforming growth factor-β signalling regulates protoscolex formation in the Echinococcus multilocularis metacestode
por: Kaethner, Marc, et al.
Publicado: (2023)