Cargando…

Unveiling the Intracellular Survival Gene Kit of Trypanosomatid Parasites

Trypanosomatids are unicellular protozoans of medical and economical relevance since they are the etiologic agents of infectious diseases in humans as well as livestock. Whereas Trypanosoma cruzi and different species of Leishmania are obligate intracellular parasites, Trypanosoma brucei and other t...

Descripción completa

Detalles Bibliográficos
Autores principales: Bartholomeu, Daniella Castanheira, de Paiva, Rita Marcia Cardoso, Mendes, Tiago A. O., DaRocha, Wanderson D., Teixeira, Santuza M. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256449/
https://www.ncbi.nlm.nih.gov/pubmed/25474314
http://dx.doi.org/10.1371/journal.ppat.1004399
_version_ 1782347586037874688
author Bartholomeu, Daniella Castanheira
de Paiva, Rita Marcia Cardoso
Mendes, Tiago A. O.
DaRocha, Wanderson D.
Teixeira, Santuza M. R.
author_facet Bartholomeu, Daniella Castanheira
de Paiva, Rita Marcia Cardoso
Mendes, Tiago A. O.
DaRocha, Wanderson D.
Teixeira, Santuza M. R.
author_sort Bartholomeu, Daniella Castanheira
collection PubMed
description Trypanosomatids are unicellular protozoans of medical and economical relevance since they are the etiologic agents of infectious diseases in humans as well as livestock. Whereas Trypanosoma cruzi and different species of Leishmania are obligate intracellular parasites, Trypanosoma brucei and other trypanosomatids develop extracellularly throughout their entire life cycle. After their genomes have been sequenced, various comparative genomic studies aimed at identifying sequences involved with host cell invasion and intracellular survival have been described. However, for only a handful of genes, most of them present exclusively in the T. cruzi or Leishmania genomes, has there been any experimental evidence associating them with intracellular parasitism. With the increasing number of published complete genome sequences of members of the trypanosomatid family, including not only different Trypanosoma and Leishmania strains and subspecies but also trypanosomatids that do not infect humans or other mammals, we may now be able to contemplate a slightly better picture regarding the specific set of parasite factors that defines each organism's mode of living and the associated disease phenotypes. Here, we review the studies concerning T. cruzi and Leishmania genes that have been implicated with cell invasion and intracellular parasitism and also summarize the wealth of new information regarding the mode of living of intracellular parasites that is resulting from comparative genome studies that are based on increasingly larger trypanosomatid genome datasets.
format Online
Article
Text
id pubmed-4256449
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-42564492014-12-11 Unveiling the Intracellular Survival Gene Kit of Trypanosomatid Parasites Bartholomeu, Daniella Castanheira de Paiva, Rita Marcia Cardoso Mendes, Tiago A. O. DaRocha, Wanderson D. Teixeira, Santuza M. R. PLoS Pathog Review Trypanosomatids are unicellular protozoans of medical and economical relevance since they are the etiologic agents of infectious diseases in humans as well as livestock. Whereas Trypanosoma cruzi and different species of Leishmania are obligate intracellular parasites, Trypanosoma brucei and other trypanosomatids develop extracellularly throughout their entire life cycle. After their genomes have been sequenced, various comparative genomic studies aimed at identifying sequences involved with host cell invasion and intracellular survival have been described. However, for only a handful of genes, most of them present exclusively in the T. cruzi or Leishmania genomes, has there been any experimental evidence associating them with intracellular parasitism. With the increasing number of published complete genome sequences of members of the trypanosomatid family, including not only different Trypanosoma and Leishmania strains and subspecies but also trypanosomatids that do not infect humans or other mammals, we may now be able to contemplate a slightly better picture regarding the specific set of parasite factors that defines each organism's mode of living and the associated disease phenotypes. Here, we review the studies concerning T. cruzi and Leishmania genes that have been implicated with cell invasion and intracellular parasitism and also summarize the wealth of new information regarding the mode of living of intracellular parasites that is resulting from comparative genome studies that are based on increasingly larger trypanosomatid genome datasets. Public Library of Science 2014-12-04 /pmc/articles/PMC4256449/ /pubmed/25474314 http://dx.doi.org/10.1371/journal.ppat.1004399 Text en © 2014 Bartholomeu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Review
Bartholomeu, Daniella Castanheira
de Paiva, Rita Marcia Cardoso
Mendes, Tiago A. O.
DaRocha, Wanderson D.
Teixeira, Santuza M. R.
Unveiling the Intracellular Survival Gene Kit of Trypanosomatid Parasites
title Unveiling the Intracellular Survival Gene Kit of Trypanosomatid Parasites
title_full Unveiling the Intracellular Survival Gene Kit of Trypanosomatid Parasites
title_fullStr Unveiling the Intracellular Survival Gene Kit of Trypanosomatid Parasites
title_full_unstemmed Unveiling the Intracellular Survival Gene Kit of Trypanosomatid Parasites
title_short Unveiling the Intracellular Survival Gene Kit of Trypanosomatid Parasites
title_sort unveiling the intracellular survival gene kit of trypanosomatid parasites
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256449/
https://www.ncbi.nlm.nih.gov/pubmed/25474314
http://dx.doi.org/10.1371/journal.ppat.1004399
work_keys_str_mv AT bartholomeudaniellacastanheira unveilingtheintracellularsurvivalgenekitoftrypanosomatidparasites
AT depaivaritamarciacardoso unveilingtheintracellularsurvivalgenekitoftrypanosomatidparasites
AT mendestiagoao unveilingtheintracellularsurvivalgenekitoftrypanosomatidparasites
AT darochawandersond unveilingtheintracellularsurvivalgenekitoftrypanosomatidparasites
AT teixeirasantuzamr unveilingtheintracellularsurvivalgenekitoftrypanosomatidparasites