High-content Analysis of Antibody Phage-display Library Selection Outputs Identifies Tumor Selective Macropinocytosis-dependent Rapidly Internalizing Antibodies

Many forms of antibody-based targeted therapeutics, including antibody drug conjugates, utilize the internalizing function of the targeting antibody to gain intracellular entry into tumor cells. Ideal antibodies for developing such therapeutics should be capable of both tumor-selective binding and e...

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Detalles Bibliográficos
Autores principales: Ha, Kevin D., Bidlingmaier, Scott M., Zhang, Yafeng, Su, Yang, Liu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256486/
https://www.ncbi.nlm.nih.gov/pubmed/25149096
http://dx.doi.org/10.1074/mcp.M114.039768

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