The Functional Landscape of Hsp27 Reveals New Cellular Processes such as DNA Repair and Alternative Splicing and Proposes Novel Anticancer Targets

Previously, we identified the stress-induced chaperone, Hsp27, as highly overexpressed in castration-resistant prostate cancer and developed an Hsp27 inhibitor (OGX-427) currently tested in phase I/II clinical trials as a chemosensitizing agent in different cancers. To better understand the Hsp27 po...

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Detalles Bibliográficos
Autores principales: Katsogiannou, Maria, Andrieu, Claudia, Baylot, Virginie, Baudot, Anaïs, Dusetti, Nelson J., Gayet, Odile, Finetti, Pascal, Garrido, Carmen, Birnbaum, Daniel, Bertucci, François, Brun, Christine, Rocchi, Palma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256507/
https://www.ncbi.nlm.nih.gov/pubmed/25277244
http://dx.doi.org/10.1074/mcp.M114.041228

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