The small protein floodgates are opening; now the functional analysis begins

Aside from a few serendipitous discoveries, small proteins of less than 50 amino acids in bacteria and 100 amino acids in eukaryotes were largely ignored due to challenges in their genetic and biochemical detection. However, with the ever-increasing availability of completed genome sequences and dee...

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Detalles Bibliográficos
Autores principales: Ramamurthi, Kumaran S, Storz, Gisela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256750/
https://www.ncbi.nlm.nih.gov/pubmed/25475548
http://dx.doi.org/10.1186/s12915-014-0096-y
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author Ramamurthi, Kumaran S
Storz, Gisela
author_facet Ramamurthi, Kumaran S
Storz, Gisela
author_sort Ramamurthi, Kumaran S
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description Aside from a few serendipitous discoveries, small proteins of less than 50 amino acids in bacteria and 100 amino acids in eukaryotes were largely ignored due to challenges in their genetic and biochemical detection. However, with the ever-increasing availability of completed genome sequences and deep sequencing, which allows analysis of genome-wide ribosome occupancy, hundreds of small proteins are now being identified. This brings to the forefront the challenges and opportunities associated with the characterization of these proteins. See research article: http://www.biomedcentral.com/1471-2164/15/946.
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spelling pubmed-42567502014-12-05 The small protein floodgates are opening; now the functional analysis begins Ramamurthi, Kumaran S Storz, Gisela BMC Biol Commentary Aside from a few serendipitous discoveries, small proteins of less than 50 amino acids in bacteria and 100 amino acids in eukaryotes were largely ignored due to challenges in their genetic and biochemical detection. However, with the ever-increasing availability of completed genome sequences and deep sequencing, which allows analysis of genome-wide ribosome occupancy, hundreds of small proteins are now being identified. This brings to the forefront the challenges and opportunities associated with the characterization of these proteins. See research article: http://www.biomedcentral.com/1471-2164/15/946. BioMed Central 2014-12-05 /pmc/articles/PMC4256750/ /pubmed/25475548 http://dx.doi.org/10.1186/s12915-014-0096-y Text en © Ramamurthi and Storz; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Ramamurthi, Kumaran S
Storz, Gisela
The small protein floodgates are opening; now the functional analysis begins
title The small protein floodgates are opening; now the functional analysis begins
title_full The small protein floodgates are opening; now the functional analysis begins
title_fullStr The small protein floodgates are opening; now the functional analysis begins
title_full_unstemmed The small protein floodgates are opening; now the functional analysis begins
title_short The small protein floodgates are opening; now the functional analysis begins
title_sort small protein floodgates are opening; now the functional analysis begins
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256750/
https://www.ncbi.nlm.nih.gov/pubmed/25475548
http://dx.doi.org/10.1186/s12915-014-0096-y
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