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AIRE acetylation and deacetylation: effect on protein stability and transactivation activity
BACKGROUND: The AIRE protein plays a remarkable role as a regulator of central tolerance by controlling the promiscuous expression of tissue-specific antigens in thymic medullary epithelial cells. Defects in AIRE gene cause the autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy, a rare...
Autores principales: | Incani, Federica, Serra, Maria Luisa, Meloni, Alessandra, Cossu, Carla, Saba, Luisella, Cabras, Tiziana, Messana, Irene, Rosatelli, Maria Cristina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256887/ https://www.ncbi.nlm.nih.gov/pubmed/25158603 http://dx.doi.org/10.1186/s12929-014-0085-z |
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