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Development and immunological assessment of VLP-based immunogens exposing the membrane-proximal region of the HIV-1 gp41 protein

BACKGROUND: The membrane-proximal external region (MPER) of HIV-1 gp41 is particularly conserved and target for the potent broadly neutralizing monoclonal antibodies (bnMAbs) 2F5, 4E10 and 10E8. Epitope focusing and stabilization present promising strategies to enhance the quality of immune response...

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Detalles Bibliográficos
Autores principales:	Benen, Thomas D, Tonks, Paul, Kliche, Alexander, Kapzan, Ruth, Heeney, Jonathan L, Wagner, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256929/ https://www.ncbi.nlm.nih.gov/pubmed/25160824 http://dx.doi.org/10.1186/s12929-014-0079-x

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