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Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection

The DEAD-box RNA helicase DDX3 is a multifunctional protein involved in all aspects of RNA metabolism, including transcription, splicing, mRNA nuclear export, translation, RNA decay and ribosome biogenesis. In addition, DDX3 is also implicated in cell cycle regulation, apoptosis, Wnt-β-catenin signa...

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Autor principal: Ariumi, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257086/
https://www.ncbi.nlm.nih.gov/pubmed/25538732
http://dx.doi.org/10.3389/fgene.2014.00423
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author Ariumi, Yasuo
author_facet Ariumi, Yasuo
author_sort Ariumi, Yasuo
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description The DEAD-box RNA helicase DDX3 is a multifunctional protein involved in all aspects of RNA metabolism, including transcription, splicing, mRNA nuclear export, translation, RNA decay and ribosome biogenesis. In addition, DDX3 is also implicated in cell cycle regulation, apoptosis, Wnt-β-catenin signaling, tumorigenesis, and viral infection. Notably, recent studies suggest that DDX3 is a component of anti-viral innate immune signaling pathways. Indeed, DDX3 contributes to enhance the induction of anti-viral mediators, interferon (IFN) regulatory factor 3 and type I IFN. However, DDX3 seems to be an important target for several viruses, such as human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV), hepatitis B virus (HBV), and poxvirus. DDX3 interacts with HIV-1 Rev or HCV Core protein and modulates its function. At least, DDX3 is required for both HIV-1 and HCV replication. Therefore, DDX3 could be a novel therapeutic target for the development of drug against HIV-1 and HCV.
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spelling pubmed-42570862014-12-23 Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection Ariumi, Yasuo Front Genet Genetics The DEAD-box RNA helicase DDX3 is a multifunctional protein involved in all aspects of RNA metabolism, including transcription, splicing, mRNA nuclear export, translation, RNA decay and ribosome biogenesis. In addition, DDX3 is also implicated in cell cycle regulation, apoptosis, Wnt-β-catenin signaling, tumorigenesis, and viral infection. Notably, recent studies suggest that DDX3 is a component of anti-viral innate immune signaling pathways. Indeed, DDX3 contributes to enhance the induction of anti-viral mediators, interferon (IFN) regulatory factor 3 and type I IFN. However, DDX3 seems to be an important target for several viruses, such as human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV), hepatitis B virus (HBV), and poxvirus. DDX3 interacts with HIV-1 Rev or HCV Core protein and modulates its function. At least, DDX3 is required for both HIV-1 and HCV replication. Therefore, DDX3 could be a novel therapeutic target for the development of drug against HIV-1 and HCV. Frontiers Media S.A. 2014-12-05 /pmc/articles/PMC4257086/ /pubmed/25538732 http://dx.doi.org/10.3389/fgene.2014.00423 Text en Copyright © 2014 Ariumi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Ariumi, Yasuo
Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection
title Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection
title_full Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection
title_fullStr Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection
title_full_unstemmed Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection
title_short Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection
title_sort multiple functions of ddx3 rna helicase in gene regulation, tumorigenesis, and viral infection
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257086/
https://www.ncbi.nlm.nih.gov/pubmed/25538732
http://dx.doi.org/10.3389/fgene.2014.00423
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