Cargando…

Enhanced local bioavailability of single or compound drugs delivery to the inner ear through application of PLGA nanoparticles via round window administration

In this paper, the potential of poly(d,l-lactide-co-glycolide acid) (PLGA) nanoparticles (NPs) for carrying single or compound drugs traversing the round window membrane (RWM) was examined after the round window (RW) administration of different NPs to guinea pigs. First, coumarin-6 was incorporated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cai, Hui, Wen, Xingxing, Wen, Lu, Tirelli, Nicola, Zhang, Xiao, Zhang, Yue, Su, Huanpeng, Yang, Fan, Chen, Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257110/ https://www.ncbi.nlm.nih.gov/pubmed/25489245 http://dx.doi.org/10.2147/IJN.S72555

Ejemplares similares

Understanding the translocation mechanism of PLGA nanoparticles across round window membrane into the inner ear: a guideline for inner ear drug delivery based on nanomedicine
por: Zhang, Liping, et al.
Publicado: (2018)

Radiologic anatomy of the round window relevant to cochlear implantation and inner ear drug delivery
por: Nguy, Peter L., et al.
Publicado: (2020)

A Window of Opportunity: Perilymph Sampling from the Round Window Membrane Can Advance Inner Ear Diagnostics and Therapeutics
por: Peter, Madeleine St., et al.
Publicado: (2022)

Efficient siRNA transfection to the inner ear through the intact round window by a novel proteidic delivery technology in the chinchilla
por: Qi, W, et al.
Publicado: (2014)

Ultrasound Microbubble–Facilitated Inner Ear Delivery of Gold Nanoparticles Involves Transient Disruption of the Tight Junction Barrier in the Round Window Membrane
por: Lin, Yi-Chun, et al.
Publicado: (2021)

Junctional Modulation of Round Window Membrane Enhances Dexamethasone Uptake into the Inner Ear and Recovery after NIHL
por: Jeong, Seong-Hun, et al.
Publicado: (2021)

The relationship between round window and ear canal Cochlear microphonic
por: Yu, Yongqiang, et al.
Publicado: (2022)

Inner Ear Therapeutics: An Overview of Middle Ear Delivery
por: Patel, Jaimin, et al.
Publicado: (2019)

Inner ear delivery: Challenges and opportunities
por: Szeto, Betsy, et al.
Publicado: (2019)

Design Study of a Round Window Piezoelectric Transducer for Active Middle Ear Implants
por: Shin, Dong Ho
Publicado: (2021)

Local Delivery of Therapeutics to the Inner Ear: The State of the Science
por: Anderson, Caroline R., et al.
Publicado: (2019)

Inner Ear Diagnostics and Drug Delivery via Microneedles
por: Leong, Stephen, et al.
Publicado: (2022)

Inner Ear
por: Arnold, Andreas, et al.
Publicado: (2010)

The Relationship Between the Third Window Abnormalities and Inner Ear Malformations in Children with Hearing Loss
por: Ceren Sarioglu, Fatma, et al.
Publicado: (2021)

Galactosylated PLGA nanoparticles for the oral delivery of resveratrol: enhanced bioavailability and in vitro anti-inflammatory activity
por: Siu, Frederick YK, et al.
Publicado: (2018)

The impact of calcium phosphate on FITC-BSA loading of sonochemically prepared PLGA nanoparticles for inner ear drug delivery elucidated by two different fluorimetric quantification methods
por: Gausterer, Julia Clara, et al.
Publicado: (2021)

Round Window Application of an Active Middle Ear Implant: A Comparison With Hearing Aid Usage in Japan
por: Iwasaki, Satoshi, et al.
Publicado: (2017)

Inner ear barriers to nanomedicine-augmented drug delivery and imaging()
por: Zou, Jing, et al.
Publicado: (2016)

Gentamicin delivery to the inner ear: Does endolymphatic hydrops matter?
por: Marques, Pedro, et al.
Publicado: (2018)

Steady streaming as a method for drug delivery to the inner ear
por: Sumner, Laura, et al.
Publicado: (2021)

Tsukushi is essential for the development of the inner ear
por: Miwa, Toru, et al.
Publicado: (2020)

Biocompatibility of Liposome Nanocarriers in the Rat Inner Ear After Intratympanic Administration
por: Zou, Jing, et al.
Publicado: (2017)

Complexity and integration in the control of inner-ear development
por: Swiderski, Donald L, et al.
Publicado: (2007)

Development and In-Silico and Ex-Vivo Validation of a Software for a Semi-Automated Segmentation of the Round Window Niche to Design a Patient Specific Implant to Treat Inner Ear Disorders
por: Matin-Mann, Farnaz, et al.
Publicado: (2023)

Round Window Stimulation of the Cochlea
por: Jenkins, Herman A., et al.
Publicado: (2021)

Proteomics and the Inner Ear
por: Thalmann, Isolde
Publicado: (2001)

Gene Delivery into the Inner Ear and Its Clinical Implications for Hearing and Balance
por: Kanzaki, Sho
Publicado: (2018)

Biopolymer Lipid Hybrid Microcarrier for Transmembrane Inner Ear Delivery of Dexamethasone
por: Dindelegan, Maximilian George, et al.
Publicado: (2022)

Comparison of Drug Availability in the Inner Ear After Oral, Transtympanic, and Combined Administration
por: Li, Yang, et al.
Publicado: (2021)

Role of Inner Ear Macrophages and Autoimmune/Autoinflammatory Mechanisms in the Pathophysiology of Inner Ear Disease
por: Miwa, Toru, et al.
Publicado: (2022)

Numerical Study and Optimization of a Novel Piezoelectric Transducer for a Round-Window Stimulating Type Middle-Ear Implant
por: Liu, Houguang, et al.
Publicado: (2019)

Application of Nanomedicine in Inner Ear Diseases
por: Lin, Qianyu, et al.
Publicado: (2022)

Nanocarriers for Inner Ear Disease Therapy
por: Xu, Xiaoxiang, et al.
Publicado: (2021)

Bioavailability and Brain-Targeting of Geniposide in Gardenia-Borneol Co-Compound by Different Administration Routes in Mice
por: Lu, Yang, et al.
Publicado: (2012)

Inner ear disturbances related to middle ear inflammation
por: Sone, Michihiko
Publicado: (2017)

Autophagy in the Vertebrate Inner Ear
por: Magariños, Marta, et al.
Publicado: (2017)

Effects of Glucocorticoids on the Inner Ear
por: Takeda, Taizo, et al.
Publicado: (2021)

Editorial: Neuroimmunology of the Inner Ear
por: Perin, Paola, et al.
Publicado: (2021)

Editorial: Autoinflammation of the inner ear
por: Nakanishi, Hiroshi, et al.
Publicado: (2022)

The comparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability
por: Ma, Yiran, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_8rsc9s114m9he6ld1d1ac6a496