Cargando…

Crystallographic study of PET radio­tracers in clinical evaluation for early diagnosis of Alzheimers

The title compound, C(24)H(25)NO(3)·2CH(3)OH, which crystallized as a methanol disolvate, has applications as a PET radiotracer in the early diagnosis of Alzheimer’s disease. The dihedral angle between the biphenyl rings is 8.2 (2)° and the heterocyclic ring adopts a half-chair conformation with the...

Descripción completa

Detalles Bibliográficos
Autores principales: Altomare, Angela, Capparelli, Elena, Carrieri, Antonio, Colabufo, Nicola A., Moliterni, Anna, Rizzi, Rosanna, Siliqi, Dritan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257311/
https://www.ncbi.nlm.nih.gov/pubmed/25484794
http://dx.doi.org/10.1107/S1600536814021400
Descripción
Sumario:The title compound, C(24)H(25)NO(3)·2CH(3)OH, which crystallized as a methanol disolvate, has applications as a PET radiotracer in the early diagnosis of Alzheimer’s disease. The dihedral angle between the biphenyl rings is 8.2 (2)° and the heterocyclic ring adopts a half-chair conformation with the N atom adopting a pyramidal geometry (bond-angle sum = 327.6°). The C atoms of both meth­oxy groups lie close to the plane of their attached ring [deviations = 0.107 (6) and 0.031 (6) Å]. In the crystal, the components are linked by O—H⋯O and O—H⋯N hydrogen bonds, generating [010] chains. C—H⋯O inter­actions are also observed.