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Crystal structure of ethyl 2-(2-fluoro­benzyl­idene)-5-(4-fluoro­phen­yl)-7-methyl-3-oxo-2,3-di­hydro-5H-1,3-thia­zolo[3,2-a]pyrimidine-6-carb­oxy­late

In the title mol­ecule, C(23)H(18)F(2)N(2)O(3)S, the 4-fluoro-substituted and 2-fluoro-substituted benzene rings form dihedral angles of 88.16 (8) and 23.1 (1)°, respectively, with the thia­zole ring. The pyrimidine ring adopts a flattened sofa conformation with the sp (3)-hydridized C atom forming...

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Detalles Bibliográficos
Autores principales: Krishnamurthy, M. S., Begum, Noor Shahina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257371/
https://www.ncbi.nlm.nih.gov/pubmed/25553039
http://dx.doi.org/10.1107/S1600536814025008
Descripción
Sumario:In the title mol­ecule, C(23)H(18)F(2)N(2)O(3)S, the 4-fluoro-substituted and 2-fluoro-substituted benzene rings form dihedral angles of 88.16 (8) and 23.1 (1)°, respectively, with the thia­zole ring. The pyrimidine ring adopts a flattened sofa conformation with the sp (3)-hydridized C atom forming the flap. In the crystal, pairs of weak C—H⋯O hydrogen bonds link mol­ecules related by twofold rotation axes, forming R (2) (2)(10) rings, which are in turn linked by weak C—H⋯N inter­actions to form chains of rings along [010]. In addition, weak C—H⋯π(arene) inter­actions link the chains into layers parallel to (001) and π–π inter­actions with a centroid–centroid distance of 3.836 (10) Å connect these layers into a three-dimensional network.