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Crystal structure of (−)-(2R,3S,4R,5R)-5-(1,3-di­thian-2-yl)-3-methyl-1-(triiso­propyl­sil­yloxy)hexane-2,4-diol

The title compound, C(20)H(42)O(3)S(2)Si, crystallized with two independent mol­ecules (A and B) in the asymmetric unit. They consist of syn,anti,anti-stereo­tetrads with a 1,3-di­thiane motif and a primary alcohol protected as the triisopropyl silyl ether. The 1,3-di­thiane ring adopts a chair conf...

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Detalles Bibliográficos
Autores principales: Cruz-Montanez, Alejandra, Piñero Cruz, Dalice M., Prieto, Jose A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257393/
https://www.ncbi.nlm.nih.gov/pubmed/25553049
http://dx.doi.org/10.1107/S160053681402443X
Descripción
Sumario:The title compound, C(20)H(42)O(3)S(2)Si, crystallized with two independent mol­ecules (A and B) in the asymmetric unit. They consist of syn,anti,anti-stereo­tetrads with a 1,3-di­thiane motif and a primary alcohol protected as the triisopropyl silyl ether. The 1,3-di­thiane ring adopts a chair conformation, while the rest of each mol­ecule displays a common zigzag conformation. There is an intra­molecular O—H⋯O hydrogen bond in each mol­ecule. In the crystal, the A and B mol­ecules are linked via O—H⋯O hydrogen bonds, forming –A–B–A--B-- chains along [010]. The absolute structure was determined by resonant scattering (anomalous scattering) [Flack parameter = 0.035 (8)].