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Crystal structure of hydrocortisone 17-butyrate
In the title compound, C(25)H(36)O(6), the two central cyclohexane rings exhibit a chair conformation. The terminal cyclohexene and cyclopentane rings are in half-chair and envelope conformations (with the C atom bearing the methyl substituent as the flap), respectively. The methyl group of the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257404/ https://www.ncbi.nlm.nih.gov/pubmed/25553020 http://dx.doi.org/10.1107/S1600536814023903 |
Sumario: | In the title compound, C(25)H(36)O(6), the two central cyclohexane rings exhibit a chair conformation. The terminal cyclohexene and cyclopentane rings are in half-chair and envelope conformations (with the C atom bearing the methyl substituent as the flap), respectively. The methyl group of the butyrate chain is disordered over two orientations, with a refined occupancy ratio of 0.742 (6):0.258 (6). Intramolecular O—H⋯O and C—H⋯O hydrogen bonds are observed. In the crystal, molecules are linked by O—H⋯O hydrogen bonds into chains running parallel to the a axis. |
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