Synthesis and Functional Characterization of Substituted Isoquinolinones as MT(2)-Selective Melatoninergic Ligands

A series of substituted isoquinolinones were synthesized and their binding affinities and functional activities towards human melatonin MT(1) and MT(2) receptors were evaluated. Structure-activity relationship analysis revealed that substituted isoquinolinones bearing a 3-methoxybenzyloxyl group at...

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Detalles Bibliográficos
Autores principales: Hu, Yueqing, Chan, King H., He, Xixin, Ho, Maurice K. C., Wong, Yung H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257560/
https://www.ncbi.nlm.nih.gov/pubmed/25479338
http://dx.doi.org/10.1371/journal.pone.0113638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257560/
https://www.ncbi.nlm.nih.gov/pubmed/25479338
http://dx.doi.org/10.1371/journal.pone.0113638

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