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Synthesis and Functional Characterization of Substituted Isoquinolinones as MT(2)-Selective Melatoninergic Ligands
A series of substituted isoquinolinones were synthesized and their binding affinities and functional activities towards human melatonin MT(1) and MT(2) receptors were evaluated. Structure-activity relationship analysis revealed that substituted isoquinolinones bearing a 3-methoxybenzyloxyl group at...
Autores principales: | Hu, Yueqing, Chan, King H., He, Xixin, Ho, Maurice K. C., Wong, Yung H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257560/ https://www.ncbi.nlm.nih.gov/pubmed/25479338 http://dx.doi.org/10.1371/journal.pone.0113638 |
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