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Genome-Wide Association Study Reveals a Polymorphism in the Podocyte Receptor RANK for the Decline of Renal Function in Coronary Patients

Impaired kidney function is a significant health problem and a major concern in clinical routine and is routinely determined by decreased glomerular filtration rate (GFR). In contrast to single assessment of a patients' kidney function providing only limited information on patients' health...

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Autores principales: Leiherer, Andreas, Muendlein, Axel, Rein, Philipp, Saely, Christoph H., Kinz, Elena, Vonbank, Alexander, Fraunberger, Peter, Drexel, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257683/
https://www.ncbi.nlm.nih.gov/pubmed/25478860
http://dx.doi.org/10.1371/journal.pone.0114240
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author Leiherer, Andreas
Muendlein, Axel
Rein, Philipp
Saely, Christoph H.
Kinz, Elena
Vonbank, Alexander
Fraunberger, Peter
Drexel, Heinz
author_facet Leiherer, Andreas
Muendlein, Axel
Rein, Philipp
Saely, Christoph H.
Kinz, Elena
Vonbank, Alexander
Fraunberger, Peter
Drexel, Heinz
author_sort Leiherer, Andreas
collection PubMed
description Impaired kidney function is a significant health problem and a major concern in clinical routine and is routinely determined by decreased glomerular filtration rate (GFR). In contrast to single assessment of a patients' kidney function providing only limited information on patients' health, serial measurements of GFR clearly improves the validity of diagnosis. The decline of kidney function has recently been reported to be predictive for mortality and vascular events in coronary patients. However, it has not been investigated for genetic association in GWA studies. This study investigates for the first time the association of cardiometabolic polymorphisms with the decline of estimated GFR during a 4 year follow up in 583 coronary patients, using the Cardio-Metabo Chip. We revealed a suggestive association with 3 polymorphisms, surpassing genome-wide significance (p = 4.0 e-7). The top hit rs17069906 (p = 5.6 e-10) is located within the genomic region of RANK, recently demonstrated to be an important player in the adaptive recovery response in podocytes and suggested as a promising therapeutic target in glomerular diseases.
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spelling pubmed-42576832014-12-15 Genome-Wide Association Study Reveals a Polymorphism in the Podocyte Receptor RANK for the Decline of Renal Function in Coronary Patients Leiherer, Andreas Muendlein, Axel Rein, Philipp Saely, Christoph H. Kinz, Elena Vonbank, Alexander Fraunberger, Peter Drexel, Heinz PLoS One Research Article Impaired kidney function is a significant health problem and a major concern in clinical routine and is routinely determined by decreased glomerular filtration rate (GFR). In contrast to single assessment of a patients' kidney function providing only limited information on patients' health, serial measurements of GFR clearly improves the validity of diagnosis. The decline of kidney function has recently been reported to be predictive for mortality and vascular events in coronary patients. However, it has not been investigated for genetic association in GWA studies. This study investigates for the first time the association of cardiometabolic polymorphisms with the decline of estimated GFR during a 4 year follow up in 583 coronary patients, using the Cardio-Metabo Chip. We revealed a suggestive association with 3 polymorphisms, surpassing genome-wide significance (p = 4.0 e-7). The top hit rs17069906 (p = 5.6 e-10) is located within the genomic region of RANK, recently demonstrated to be an important player in the adaptive recovery response in podocytes and suggested as a promising therapeutic target in glomerular diseases. Public Library of Science 2014-12-05 /pmc/articles/PMC4257683/ /pubmed/25478860 http://dx.doi.org/10.1371/journal.pone.0114240 Text en © 2014 Leiherer et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Leiherer, Andreas
Muendlein, Axel
Rein, Philipp
Saely, Christoph H.
Kinz, Elena
Vonbank, Alexander
Fraunberger, Peter
Drexel, Heinz
Genome-Wide Association Study Reveals a Polymorphism in the Podocyte Receptor RANK for the Decline of Renal Function in Coronary Patients
title Genome-Wide Association Study Reveals a Polymorphism in the Podocyte Receptor RANK for the Decline of Renal Function in Coronary Patients
title_full Genome-Wide Association Study Reveals a Polymorphism in the Podocyte Receptor RANK for the Decline of Renal Function in Coronary Patients
title_fullStr Genome-Wide Association Study Reveals a Polymorphism in the Podocyte Receptor RANK for the Decline of Renal Function in Coronary Patients
title_full_unstemmed Genome-Wide Association Study Reveals a Polymorphism in the Podocyte Receptor RANK for the Decline of Renal Function in Coronary Patients
title_short Genome-Wide Association Study Reveals a Polymorphism in the Podocyte Receptor RANK for the Decline of Renal Function in Coronary Patients
title_sort genome-wide association study reveals a polymorphism in the podocyte receptor rank for the decline of renal function in coronary patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257683/
https://www.ncbi.nlm.nih.gov/pubmed/25478860
http://dx.doi.org/10.1371/journal.pone.0114240
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