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Randomised Trial of Text Messaging on Adherence to Cardiovascular Preventive Treatment (INTERACT Trial)
BACKGROUND: About one third of patients prescribed blood pressure or lipid-lowering drugs for the prevention of coronary heart disease and stroke do not take their medication as prescribed. We conducted a randomized trial to evaluate text messaging as a means of improving adherence to cardiovascular...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257733/ https://www.ncbi.nlm.nih.gov/pubmed/25479285 http://dx.doi.org/10.1371/journal.pone.0114268 |
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author | Wald, David S. Bestwick, Jonathan P. Raiman, Lewis Brendell, Rebecca Wald, Nicholas J. |
author_facet | Wald, David S. Bestwick, Jonathan P. Raiman, Lewis Brendell, Rebecca Wald, Nicholas J. |
author_sort | Wald, David S. |
collection | PubMed |
description | BACKGROUND: About one third of patients prescribed blood pressure or lipid-lowering drugs for the prevention of coronary heart disease and stroke do not take their medication as prescribed. We conducted a randomized trial to evaluate text messaging as a means of improving adherence to cardiovascular disease preventive treatment. METHODS: 303 patients taking blood pressure and/or lipid-lowering medications were randomly assigned to being sent text messages (Text group, 151) or not being sent them (No text group, 152). Texts were sent daily for 2 weeks, alternate days for 2 weeks and weekly thereafter for 22 weeks (6 months overall), using an automated computer programme. Patients were asked to respond on whether they had taken their medication, whether the text reminded them to do so if they had forgotten, and if they had not taken their medication to determine if there was a reason for not doing so. At 6 months, use of medication was assessed. RESULTS: Two patients were lost to follow-up, providing data on 301 for analysis. In the No text group 38/151 (25%) took less than 80% of the prescribed regimen (ie. stopped medication completely or took it on fewer than 22 of the last 28 days of follow-up) compared to 14/150 patients (9%) in the Text group – an improvement in adherence affecting 16 per 100 patients (95% CI 7 to 24), p<0.001. The texts reminded 98/151 patients (65%) to take medication on at least one occasion and lead to 20/151 (13%) who stopped taking medication because of concern over efficacy or side-effects, resuming treatment. CONCLUSIONS: In patients taking blood pressure or lipid-lowering treatment for the prevention of cardiovascular disease, text messaging improved medication adherence compared with no text messaging. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN74757601 |
format | Online Article Text |
id | pubmed-4257733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-42577332014-12-15 Randomised Trial of Text Messaging on Adherence to Cardiovascular Preventive Treatment (INTERACT Trial) Wald, David S. Bestwick, Jonathan P. Raiman, Lewis Brendell, Rebecca Wald, Nicholas J. PLoS One Research Article BACKGROUND: About one third of patients prescribed blood pressure or lipid-lowering drugs for the prevention of coronary heart disease and stroke do not take their medication as prescribed. We conducted a randomized trial to evaluate text messaging as a means of improving adherence to cardiovascular disease preventive treatment. METHODS: 303 patients taking blood pressure and/or lipid-lowering medications were randomly assigned to being sent text messages (Text group, 151) or not being sent them (No text group, 152). Texts were sent daily for 2 weeks, alternate days for 2 weeks and weekly thereafter for 22 weeks (6 months overall), using an automated computer programme. Patients were asked to respond on whether they had taken their medication, whether the text reminded them to do so if they had forgotten, and if they had not taken their medication to determine if there was a reason for not doing so. At 6 months, use of medication was assessed. RESULTS: Two patients were lost to follow-up, providing data on 301 for analysis. In the No text group 38/151 (25%) took less than 80% of the prescribed regimen (ie. stopped medication completely or took it on fewer than 22 of the last 28 days of follow-up) compared to 14/150 patients (9%) in the Text group – an improvement in adherence affecting 16 per 100 patients (95% CI 7 to 24), p<0.001. The texts reminded 98/151 patients (65%) to take medication on at least one occasion and lead to 20/151 (13%) who stopped taking medication because of concern over efficacy or side-effects, resuming treatment. CONCLUSIONS: In patients taking blood pressure or lipid-lowering treatment for the prevention of cardiovascular disease, text messaging improved medication adherence compared with no text messaging. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN74757601 Public Library of Science 2014-12-05 /pmc/articles/PMC4257733/ /pubmed/25479285 http://dx.doi.org/10.1371/journal.pone.0114268 Text en © 2014 Wald et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Wald, David S. Bestwick, Jonathan P. Raiman, Lewis Brendell, Rebecca Wald, Nicholas J. Randomised Trial of Text Messaging on Adherence to Cardiovascular Preventive Treatment (INTERACT Trial) |
title | Randomised Trial of Text Messaging on Adherence to Cardiovascular Preventive Treatment (INTERACT Trial) |
title_full | Randomised Trial of Text Messaging on Adherence to Cardiovascular Preventive Treatment (INTERACT Trial) |
title_fullStr | Randomised Trial of Text Messaging on Adherence to Cardiovascular Preventive Treatment (INTERACT Trial) |
title_full_unstemmed | Randomised Trial of Text Messaging on Adherence to Cardiovascular Preventive Treatment (INTERACT Trial) |
title_short | Randomised Trial of Text Messaging on Adherence to Cardiovascular Preventive Treatment (INTERACT Trial) |
title_sort | randomised trial of text messaging on adherence to cardiovascular preventive treatment (interact trial) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257733/ https://www.ncbi.nlm.nih.gov/pubmed/25479285 http://dx.doi.org/10.1371/journal.pone.0114268 |
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