Evidence for a group II intron-like catalytic triplex in the spliceosome

To catalyze pre-mRNA splicing, U6 snRNA positions two metals that interact directly with the scissile phosphates. The U6 metal ligands correspond stereospecifically to metal ligands within the catalytic domain V of a group II self-splicing intron. In domain V, the ligands are organized by base-tripl...

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Detalles Bibliográficos
Autores principales: Fica, Sebastian M., Mefford, Melissa A., Piccirilli, Joseph A., Staley, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257784/
https://www.ncbi.nlm.nih.gov/pubmed/24747940
http://dx.doi.org/10.1038/nsmb.2815

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