Targeting α4β7 integrin reduces mucosal transmission of SIV and protects GALT from infection

α4β7 integrin expressing CD4(+) T cells preferentially traffic to gut-associated lymphoid tissues (GALT) and play a key role in HIV/SIV pathogenesis. The administration of an anti-α4β7 monoclonal antibody during acute infection protects macaques from transmission following repeated low-dose intra-va...

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Detalles Bibliográficos
Autores principales: Byrareddy, Siddappa N., Kallam, Brianne, Arthos, James, Cicala, Claudia, Nawaz, Fatima, Hiatt, Joseph, Kersh, Ellen N., McNicholl, Janet M., Hanson, Debra, Reimann, Keith A., Brameier, Markus, Walter, Lutz, Rogers, Kenneth, Mayne, Ann E., Dunbar, Paul, Villinger, Tara, Little, Dawn, Parslow, Tristram G., Santangelo, Philip J., Villinger, Francois, Fauci, Anthony S., Ansari, Aftab A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257865/
https://www.ncbi.nlm.nih.gov/pubmed/25419708
http://dx.doi.org/10.1038/nm.3715
Descripción
Sumario:α4β7 integrin expressing CD4(+) T cells preferentially traffic to gut-associated lymphoid tissues (GALT) and play a key role in HIV/SIV pathogenesis. The administration of an anti-α4β7 monoclonal antibody during acute infection protects macaques from transmission following repeated low-dose intra-vaginal challenges with SIVmac251. In treated animals that became infected the GALT was significantly protected and CD4(+) T–cell numbers were maintained. Thus, targeting α4β7 reduces mucosal transmission of SIV in macaques.

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