Cargando…
Targeting α4β7 integrin reduces mucosal transmission of SIV and protects GALT from infection
α4β7 integrin expressing CD4(+) T cells preferentially traffic to gut-associated lymphoid tissues (GALT) and play a key role in HIV/SIV pathogenesis. The administration of an anti-α4β7 monoclonal antibody during acute infection protects macaques from transmission following repeated low-dose intra-va...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257865/ https://www.ncbi.nlm.nih.gov/pubmed/25419708 http://dx.doi.org/10.1038/nm.3715 |
| _version_ | 1782347818534436864 |
|---|---|
| author | Byrareddy, Siddappa N. Kallam, Brianne Arthos, James Cicala, Claudia Nawaz, Fatima Hiatt, Joseph Kersh, Ellen N. McNicholl, Janet M. Hanson, Debra Reimann, Keith A. Brameier, Markus Walter, Lutz Rogers, Kenneth Mayne, Ann E. Dunbar, Paul Villinger, Tara Little, Dawn Parslow, Tristram G. Santangelo, Philip J. Villinger, Francois Fauci, Anthony S. Ansari, Aftab A. |
| author_facet | Byrareddy, Siddappa N. Kallam, Brianne Arthos, James Cicala, Claudia Nawaz, Fatima Hiatt, Joseph Kersh, Ellen N. McNicholl, Janet M. Hanson, Debra Reimann, Keith A. Brameier, Markus Walter, Lutz Rogers, Kenneth Mayne, Ann E. Dunbar, Paul Villinger, Tara Little, Dawn Parslow, Tristram G. Santangelo, Philip J. Villinger, Francois Fauci, Anthony S. Ansari, Aftab A. |
| author_sort | Byrareddy, Siddappa N. |
| collection | PubMed |
| description | α4β7 integrin expressing CD4(+) T cells preferentially traffic to gut-associated lymphoid tissues (GALT) and play a key role in HIV/SIV pathogenesis. The administration of an anti-α4β7 monoclonal antibody during acute infection protects macaques from transmission following repeated low-dose intra-vaginal challenges with SIVmac251. In treated animals that became infected the GALT was significantly protected and CD4(+) T–cell numbers were maintained. Thus, targeting α4β7 reduces mucosal transmission of SIV in macaques. |
| format | Online Article Text |
| id | pubmed-4257865 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-42578652015-06-01 Targeting α4β7 integrin reduces mucosal transmission of SIV and protects GALT from infection Byrareddy, Siddappa N. Kallam, Brianne Arthos, James Cicala, Claudia Nawaz, Fatima Hiatt, Joseph Kersh, Ellen N. McNicholl, Janet M. Hanson, Debra Reimann, Keith A. Brameier, Markus Walter, Lutz Rogers, Kenneth Mayne, Ann E. Dunbar, Paul Villinger, Tara Little, Dawn Parslow, Tristram G. Santangelo, Philip J. Villinger, Francois Fauci, Anthony S. Ansari, Aftab A. Nat Med Article α4β7 integrin expressing CD4(+) T cells preferentially traffic to gut-associated lymphoid tissues (GALT) and play a key role in HIV/SIV pathogenesis. The administration of an anti-α4β7 monoclonal antibody during acute infection protects macaques from transmission following repeated low-dose intra-vaginal challenges with SIVmac251. In treated animals that became infected the GALT was significantly protected and CD4(+) T–cell numbers were maintained. Thus, targeting α4β7 reduces mucosal transmission of SIV in macaques. 2014-11-24 2014-12 /pmc/articles/PMC4257865/ /pubmed/25419708 http://dx.doi.org/10.1038/nm.3715 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Byrareddy, Siddappa N. Kallam, Brianne Arthos, James Cicala, Claudia Nawaz, Fatima Hiatt, Joseph Kersh, Ellen N. McNicholl, Janet M. Hanson, Debra Reimann, Keith A. Brameier, Markus Walter, Lutz Rogers, Kenneth Mayne, Ann E. Dunbar, Paul Villinger, Tara Little, Dawn Parslow, Tristram G. Santangelo, Philip J. Villinger, Francois Fauci, Anthony S. Ansari, Aftab A. Targeting α4β7 integrin reduces mucosal transmission of SIV and protects GALT from infection |
| title | Targeting α4β7 integrin reduces mucosal transmission of SIV and protects GALT from infection |
| title_full | Targeting α4β7 integrin reduces mucosal transmission of SIV and protects GALT from infection |
| title_fullStr | Targeting α4β7 integrin reduces mucosal transmission of SIV and protects GALT from infection |
| title_full_unstemmed | Targeting α4β7 integrin reduces mucosal transmission of SIV and protects GALT from infection |
| title_short | Targeting α4β7 integrin reduces mucosal transmission of SIV and protects GALT from infection |
| title_sort | targeting α4β7 integrin reduces mucosal transmission of siv and protects galt from infection |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257865/ https://www.ncbi.nlm.nih.gov/pubmed/25419708 http://dx.doi.org/10.1038/nm.3715 |
| work_keys_str_mv | AT byrareddysiddappan targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT kallambrianne targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT arthosjames targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT cicalaclaudia targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT nawazfatima targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT hiattjoseph targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT kershellenn targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT mcnicholljanetm targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT hansondebra targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT reimannkeitha targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT brameiermarkus targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT walterlutz targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT rogerskenneth targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT mayneanne targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT dunbarpaul targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT villingertara targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT littledawn targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT parslowtristramg targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT santangelophilipj targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT villingerfrancois targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT faucianthonys targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection AT ansariaftaba targetinga4b7integrinreducesmucosaltransmissionofsivandprotectsgaltfrominfection |