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β-catenin mediates behavioral resilience through Dicer1/microRNA regulation
β-catenin is a multi-functional protein that plays an important role in the mature central nervous system; its dysfunction has been implicated in several neuropsychiatric disorders, including depression. Here we show that β-catenin mediates pro-resilient and anxiolytic effects in mice in the nucleus...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257892/ https://www.ncbi.nlm.nih.gov/pubmed/25383518 http://dx.doi.org/10.1038/nature13976 |
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author | Dias, Caroline Feng, Jian Sun, Haosheng Shao, Ning-yi Mazei-Robison, Michelle S. Damez-Werno, Diane Scobie, Kimberly Bagot, Rosemary LaBonte, Benoit Ribeiro, Efrain Liu, XiaoChuan Kennedy, Pamela Vialou, Vincent Ferguson, Deveroux Pena, Catherine Calipari, Erin Koo, Jawook Mouzon, Ezekiell Ghose, Subruto Tamminga, Carol Neve, Rachael Shen, Li Nestler, Eric J. |
author_facet | Dias, Caroline Feng, Jian Sun, Haosheng Shao, Ning-yi Mazei-Robison, Michelle S. Damez-Werno, Diane Scobie, Kimberly Bagot, Rosemary LaBonte, Benoit Ribeiro, Efrain Liu, XiaoChuan Kennedy, Pamela Vialou, Vincent Ferguson, Deveroux Pena, Catherine Calipari, Erin Koo, Jawook Mouzon, Ezekiell Ghose, Subruto Tamminga, Carol Neve, Rachael Shen, Li Nestler, Eric J. |
author_sort | Dias, Caroline |
collection | PubMed |
description | β-catenin is a multi-functional protein that plays an important role in the mature central nervous system; its dysfunction has been implicated in several neuropsychiatric disorders, including depression. Here we show that β-catenin mediates pro-resilient and anxiolytic effects in mice in the nucleus accumbens, a key brain reward region, an effect mediated by D2-type medium spiny neurons. Using genome-wide β-catenin enrichment mapping, we identify Dicer1—important in small RNA (e.g., microRNA) biogenesis—as a β-catenin target gene that mediates resilience. Small RNA profiling after excising β-catenin from nucleus accumbens in the context of chronic stress reveals β-catenin-dependent microRNA regulation associated with resilience. Together, these findings establish β-catenin as a critical regulator in the development of behavioral resilience, activating a network that includes Dicer1 and downstream microRNAs. We thus present a foundation for the development of novel therapeutic targets to promote stress resilience. |
format | Online Article Text |
id | pubmed-4257892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
record_format | MEDLINE/PubMed |
spelling | pubmed-42578922015-06-04 β-catenin mediates behavioral resilience through Dicer1/microRNA regulation Dias, Caroline Feng, Jian Sun, Haosheng Shao, Ning-yi Mazei-Robison, Michelle S. Damez-Werno, Diane Scobie, Kimberly Bagot, Rosemary LaBonte, Benoit Ribeiro, Efrain Liu, XiaoChuan Kennedy, Pamela Vialou, Vincent Ferguson, Deveroux Pena, Catherine Calipari, Erin Koo, Jawook Mouzon, Ezekiell Ghose, Subruto Tamminga, Carol Neve, Rachael Shen, Li Nestler, Eric J. Nature Article β-catenin is a multi-functional protein that plays an important role in the mature central nervous system; its dysfunction has been implicated in several neuropsychiatric disorders, including depression. Here we show that β-catenin mediates pro-resilient and anxiolytic effects in mice in the nucleus accumbens, a key brain reward region, an effect mediated by D2-type medium spiny neurons. Using genome-wide β-catenin enrichment mapping, we identify Dicer1—important in small RNA (e.g., microRNA) biogenesis—as a β-catenin target gene that mediates resilience. Small RNA profiling after excising β-catenin from nucleus accumbens in the context of chronic stress reveals β-catenin-dependent microRNA regulation associated with resilience. Together, these findings establish β-catenin as a critical regulator in the development of behavioral resilience, activating a network that includes Dicer1 and downstream microRNAs. We thus present a foundation for the development of novel therapeutic targets to promote stress resilience. 2014-11-12 2014-12-04 /pmc/articles/PMC4257892/ /pubmed/25383518 http://dx.doi.org/10.1038/nature13976 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Dias, Caroline Feng, Jian Sun, Haosheng Shao, Ning-yi Mazei-Robison, Michelle S. Damez-Werno, Diane Scobie, Kimberly Bagot, Rosemary LaBonte, Benoit Ribeiro, Efrain Liu, XiaoChuan Kennedy, Pamela Vialou, Vincent Ferguson, Deveroux Pena, Catherine Calipari, Erin Koo, Jawook Mouzon, Ezekiell Ghose, Subruto Tamminga, Carol Neve, Rachael Shen, Li Nestler, Eric J. β-catenin mediates behavioral resilience through Dicer1/microRNA regulation |
title | β-catenin mediates behavioral resilience through Dicer1/microRNA regulation |
title_full | β-catenin mediates behavioral resilience through Dicer1/microRNA regulation |
title_fullStr | β-catenin mediates behavioral resilience through Dicer1/microRNA regulation |
title_full_unstemmed | β-catenin mediates behavioral resilience through Dicer1/microRNA regulation |
title_short | β-catenin mediates behavioral resilience through Dicer1/microRNA regulation |
title_sort | β-catenin mediates behavioral resilience through dicer1/microrna regulation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257892/ https://www.ncbi.nlm.nih.gov/pubmed/25383518 http://dx.doi.org/10.1038/nature13976 |
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