Neurofibromatosis Type 1 and Chronic Neurological Conditions in the United States: An Administrative Claims Analysis

PURPOSE: Neurofibromatosis Type 1 (NF1) has been linked to several neurological conditions including: epilepsy, Parkinson's disease, headache, multiple sclerosis, and sleep disturbances, predominantly through case reports and series that lack comparison groups. Our objective was to assess whether specific neurological conditions occur more frequently in individuals with NF1 vs. those without NF1. METHODS: We used the 2006-2010 MarketScan Commercial Claims and Encounters database to examine associations between neurological conditions and NF1. The NF1 group was identified through ≥2 ICD-9-CM NF codes (237.70, 237.71) occurring ≥30 days apart or one inpatient NF code. A non-NF1 comparison group was frequency-matched to the NF1 group on age and enrollment length at a 10:1 ratio. Unconditional logistic regression was employed to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for associations between NF and neurological conditions. RESULTS: Compared to the non-NF1 group (n=85,790), the NF1 group (n=8,579) had a significantly higher odds of health insurance claims for epilepsy (OR=7.3; 95% CI 6.4-8.3), Parkinson's disease (OR=3.1; 95% CI 1.3-7.5), headache (OR=2.9, 95% CI 2.6-3.1), multiple sclerosis (OR=1.9, 95% CI 1.2-2.9), and sleep disturbances/disorder (OR=1.4, 95% CI 1.2-3.6). CONCLUSION: This large study provides strong evidence for positive associations between several neurological conditions and NF1.