A B-cell targeting virus disrupts potentially protective genomic methylation patterns in lymphoid tissue by increasing global 5-hydroxymethylcytosine levels

The mechanisms by which viruses modulate the immune system include changes in host genomic methylation. 5-hydroxymethylcytosine (5hmC) is the catalytic product of the Tet (Ten-11 translocation) family of enzymes and may serve as an intermediate of DNA demethylation. Recent reports suggest that 5hmC...

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Detalles Bibliográficos
Autores principales: Ciccone, Nick A, Mwangi, William, Ruzov, Alexey, Smith, Lorraine P, Butter, Colin, Nair, Venugopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258027/
https://www.ncbi.nlm.nih.gov/pubmed/25338704
http://dx.doi.org/10.1186/s13567-014-0108-5

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