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Dissecting and engineering of the TetR family regulator SACE_7301 for enhanced erythromycin production in Saccharopolyspora erythraea

BACKGROUND: Saccharopolyspora erythraea was extensively utilized for the industrial-scale production of erythromycin A (Er-A), a macrolide antibiotic commonly used in human medicine. Yet, S. erythraea lacks regulatory genes in the erythromycin biosynthetic gene (ery) cluster, hampering efforts to en...

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Detalles Bibliográficos
Autores principales:	Wu, Hang, Chen, Meng, Mao, Yongrong, Li, Weiwei, Liu, Jingtao, Huang, Xunduan, Zhou, Ying, Ye, Bang-Ce, Zhang, Lixin, Weaver, David T, Zhang, Buchang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258057/ https://www.ncbi.nlm.nih.gov/pubmed/25391994 http://dx.doi.org/10.1186/s12934-014-0158-4

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