Closed-loop optimization of chromatography column sizing strategies in biopharmaceutical manufacture

BACKGROUND: This paper considers a real-world optimization problem involving the identification of cost-effective equipment sizing strategies for the sequence of chromatography steps employed to purify biopharmaceuticals. Tackling this problem requires solving a combinatorial optimization problem su...

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Detalles Bibliográficos
Autores principales: Allmendinger, Richard, Simaria, Ana S, Turner, Richard, Farid, Suzanne S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258073/
https://www.ncbi.nlm.nih.gov/pubmed/25506115
http://dx.doi.org/10.1002/jctb.4267

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